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Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery (Update in Intensive Care and Emergency Medicine, 44) 🔍
J. L. Vincent (auth.), Edward Abraham MD, Mervyn Singer MD (eds.) Springer-Verlag Berlin Heidelberg, Update in Intensive Care and Emergency Medicine, Update in Intensive Care and Emergency Medicine 44, 1, 2007
英语 [en] · PDF · 6.9MB · 2007 · 📘 非小说类图书 · 🚀/lgli/lgrs/nexusstc/scihub/upload/zlib · Save
描述
There have been tremendous advances in understanding the cellular mechanisms involved in sepsis and contributing to the development of multiple organ dysfunction and mortality in this setting. The chapters in this book provide up-to-date insights into important pathways that are initiated by sepsis.
Doody Review Services Reviewer: David J. Dries, MD(University of Minnesota Medical School)
Description: This collection of essays, volume 44 in the Update in Intensive Care and Emergency Medicine series, describes specific patterns and mediators of organ failure in the setting of infection.
Purpose: Global mediators, cellular and tissue-specific changes in the setting of infection are collected from reports of the laboratories doing this work.
Audience: Senior trainees and practitioners in multidisciplinary critical care medicine are an appropriate audience for this book edited and written by an international group of critical care and sepsis leaders.
Features: After introductory comments that provide a unifying force for the presentations, mediators of inflammation are discussed followed by components of the pattern of cellular injury seen in sepsis. Later chapters include metabolic changes and a concluding group of essays focus on organ specific dysfunction. Chapters are well written and include line drawings and tables to summarize data. An ample reference list follows each presentation with references dating to within two years of publication, which represent original work.
Assessment: This is a good compilation of recent work done at the level of cytokines, cells, and tissues to help understand and treat this important problem. Consistent with clinical practice, cellular and organ dysfunction are emphasized while we still know relatively little about the tipping point between cell and tissue death and recovery. This is a worthy overview for the academic clinician facing sepsis at the bedside.
备用文件名
lgli/A:\_for_add\springeruns\10.1007%2F3-540-30328-6.pdf
备用文件名
lgrsnf/A:\_for_add\springeruns\10.1007%2F3-540-30328-6.pdf
备用文件名
nexusstc/Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery/12ff51a89c1209c99af53291c8c30110.pdf
备用文件名
scihub/10.1007/3-540-30328-6.pdf
备用文件名
zlib/Medicine/J. L. Vincent (auth.), Edward Abraham MD, Mervyn Singer MD (eds.)/Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery_2194414.pdf
备选标题
Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery (Update in Intensive Care Medicine Book 44)
备选标题
Mechanisms of sepsis induced organ dysfunction and recovery with 22 tables
备选作者
Theodore W. Berger; John K. Chapin; Greg A. Gerhardt; Dennis J. McFarland; Jose C. Principe; Walid V
备用出版商
Springer Berlin Heidelberg : Imprint: Springer
备用出版商
Springer Spektrum. in Springer-Verlag GmbH
备用出版商
Steinkopff. in Springer-Verlag GmbH
备用版本
Update in intensive care and emergency medicine, 44, Berlin ; New York, ©2007
备用版本
Update in intensive care medicine, 1st ed. 2007, Berlin, Heidelberg, 2007
备用版本
Springer Nature, Berlin, 2007
备用版本
1 edition, November 14, 2006
备用版本
Germany, Germany
备用版本
Oct 11, 2006
备用版本
2007, 2006
元数据中的注释
sm33611246
元数据中的注释
producers:
Acrobat Distiller 6.0 (Windows)
元数据中的注释
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备用描述
Setting the Scene....Pages 1-14
Front Matter....Pages 15-15
Genetics and Severe Sepsis....Pages 17-33
Cell Signaling Pathways of the Innate Immune System During Acute Inflammation....Pages 35-53
Early-Onset Pro-inflammatory Cytokines....Pages 55-66
The Significance of HMGB1, a Late-Acting Pro-inflammatory Cytokine....Pages 67-75
Nitric Oxide....Pages 77-95
Involvement of Reactive Oxygen and Nitrogen Species in the Pathogenesis of Acute Lung Injury....Pages 97-111
Heat Shock Proteins in Inflammation....Pages 113-121
Fibrosis in the Acute Respiratory Distress Syndrome....Pages 123-135
Resolution of Inflammation....Pages 137-157
Front Matter....Pages 159-159
Compartmentalized Activation of Immune Cells During Sepsis and Organ Dysfunction....Pages 161-182
The Neutrophil in the Pathogenesis of Multiple Organ Dysfunction Syndrome....Pages 183-201
The Role of the Macrophage....Pages 203-210
The Role of the Endothelium....Pages 211-227
Differential Effects of Pro-Inflammatory Mediators on Alveolar Epithelial Barrier Function....Pages 229-235
Front Matter....Pages 237-237
Macrocirculatory Disturbances....Pages 239-247
The Microcirculation Is a Vulnerable Organ in Sepsis....Pages 249-262
The Cholinergic Anti-inflammatory Pathway: Connecting the Mind and Body....Pages 263-272
Coagulation in Sepsis....Pages 273-285
The Role of Insulin and Blood Glucose Control....Pages 287-297
Front Matter....Pages 237-237
Dysfunction of the Bioenergetic Pathway....Pages 299-310
Metabolic Pathways....Pages 311-320
Cell Death and Acute Lung Injury....Pages 321-334
Mechanisms of Immunodepression after Central Nervous System Injury....Pages 335-350
Front Matter....Pages 351-351
Pulmonary Dysfunction....Pages 353-368
The Gut....Pages 369-381
Endogenous Danger Signals in Liver Injury: Role of High Mobility Group Box Protein-1....Pages 383-391
Sepsis-induced Acute Renal Failure and Recovery....Pages 393-405
Sepsis-Induced Brain Dysfunction....Pages 407-414
Myocardial Depression in Sepsis and Septic Shock....Pages 415-435
Skeletal Muscle....Pages 437-447
开源日期
2013-10-20
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