Wolf's discovery demonstrating that a reporter gene is expressed in myocytes subsequent to injection of naked DNA, was exploited by immunologists and vaccinologists to develop a new generation of vaccines. This observation galvanized the research and in a short lapse of time, an oceanic volume of knowledge has been accumulated. The research carried out in a variety of animal models showed the efficacy of genetic immunization against viruses, bacteria, and some parasites by the ability to induce a strong priming effect resulting from long-lasting persistence of plasmid as episomes. Furthermore, it was demonstrated that newborn or infant immune unresponsiveness to classical vaccines can be corrected by genetic immunization. The applications of genetic immunization for prophylaxis of infections was extended to immunotherapy, namely, cancerous, auto­ immune, and allergic diseases. Immunologists have provided pertinent information on the cellular basis of the immune responses elicited by genetic immunization, and molecular biologists have established the molecular basis of intrinsic adjuvant properties of plasmids.

scihub/10.1007/978-1-4757-3163-7_fm.pdf

zlib/no-category/Bona, Constantin A.; Bot, Adrian I/Genetic Immunization || || Front_matter_53517945.pdf

Constantin A. Bona, Adrian I. Bot (auth.)

Adrian Bot; Constantin A. Bona

Springer Nature

Springer US

United States, United States of America

Springer Nature, New York, NY, 2013

Boston, MA, 2000

1, 20130314

sm21120110

sm23178309

This book presents the critical information attendant to developing vaccines using the genetic basis of immunology. The authors explore which techniques and experimental paths can be pursued so that efficacious results in human trials can be reasonably expected for the treatment of bacterial, fungal, viral, and autoimmune diseases, as well as cancers. A chapter on the genetic vaccination of neonates with virus or plasmid DNA is also included

2013-11-24