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nexusstc/The Expanded Endoscopic Endonasal Approach for Primary and Recurrent Craniopharyngiomas/21bb2113b117bf293a98966accd6557b.pdf
The Expanded Endoscopic Endonasal Approach for Primary and Recurrent Craniopharyngiomas 🔍
Domenico Solari; Daniel M. Prevedello; Daniel F. Kelly; Nancy McLaughlin; Leo F. S. Ditzel Filho; Ricardo L. Carrau; Amin B. Kassam Springer Netherlands, Tumors of the Central Nervous System, Volume 8, 2012
英语 [en] · PDF · 0.4MB · 2012 · 🤨 其他 · nexusstc · Save
描述
Annotation With tens of thousands of new CNS tumor cases each year in the US alone, this series of publications is a valuable aid to the diagnosis and treatment of these problematic neoplasms. Now, the eighth in the set returns to the topic of brain tumors, dealing with seven distinct types: astrocytoma, medulloblastoma, retinoblastoma, chordoma, craniopharyngioma, oligodendroglioma, and ependymoma. After updating the classification of medulloblastoma the volume provides an overview of ependymoma as well as describing the delineation of prognosis based on the genetic aberrations of the latter patients. The material offers key insights into the molecular pathways involved in tumor biology, such as the role of E-cadherin gene instability, carbonic anhydrase II, urokinase plasminogen activator, and Wnt signaling in meningioma. Contributors explain the genetic and clinical features associated with recurring meningioma, including the role played by erythropoietin receptor, and examine the way in which OTX2 transcription factor functions as an oncogene in medulloblastoma. With much more besides, including discussion of the molecular mechanisms that result in resistance to chemotherapy in medulloblastoma, this volume and its companions have a positive role to play in inspiring a new generation of researchers to design new drugs that are better targetedand thus more effective
备选标题
Tumors of the Central Nervous System, Volume 8: Astrocytoma, Medulloblastoma, Retinoblastoma, Chordoma, Craniopharyngioma, Oligodendroglioma, and Ependymoma (Tumors of the Central Nervous System, 8)
备选作者
Hayat, M. A. (edt)
备选作者
Scot P. Hillier
备选作者
M. A. Hayat
备用出版商
Springer Science + Business Media BV
备用出版商
Springer London, Limited
备用版本
Tumors of the Central Nervous System Ser, New York, June 2012
备用版本
Tumors of the Central Nervous System, 8, Dordrecht, 2012
备用版本
Springer Nature, Dordrecht, 2012
备用版本
Netherlands, Netherlands
备用版本
Dordrecht, 2011-<2015>
备用版本
2012, PS, 2012
元数据中的注释
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元数据中的注释
Referenced by: doi:10.3171/jns-07/10/0713 doi:10.3171/2009.2.jns081026 doi:10.1227/01.neu.0000134287.19377.a2 doi:10.1227/01.neu.0000303220.55393.73 doi:10.1227/01.neu.0000249211.89096.25 doi:10.1227/01.neu.0000339121.20101.85 doi:10.3171/jns.2005.102.5.0832 doi:10.3171/jns.1999.90.2.0237 doi:10.3171/jns/2008/109/7/0006 doi:10.1097/01.mlg.0000234933.37779.e4 doi:10.1016/0090-3019(92)90229-g doi:10.1007/s11102-006-0413-8 doi:10.3171/jns/2008/108/4/0715 doi:10.1227/01.neu.0000317374.30443.23 doi:10.1227/01.neu.0000297074.13423.f5 doi:10.3171/jns.2007.106.3.400 doi:10.3171/jns.1980.52.5.0661 doi:10.1227/01.neu.0000326017.84315.1f doi:10.3171/jns.2005.103.2.0224 doi:10.1016/0360-3016(95)00175-x doi:10.1159/000120866 doi:10.1007/bf01772817 doi:10.1227/00006123-199412000-00001 doi:10.1159/000120871 doi:10.3171/jns.1990.73.1.0003
备用描述
Advantages and limitations of biomarkers in gliomagenesis are described. Molecular subtypes of gliomas are detailed. The role played by TP53 gene mutation in the deadliest brain tumor, glioblastoma multiforme, is pointed out. The role of mutations of IDH1 and IDH2, and isocitrate dehydrogenases in malignant gliomas are presented. Metabolic differences in different regions of the glioma tumor are clarified. Various types of imaging modalities, including PET and SPECT, to diagnose gliomas in general and glioblastoma in particular in patients are explained in detail. Both low-grade and high-grade
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