反馈文件质量
scihub/10.1007/978-94-007-4213-0.pdf
Tumors of the Central Nervous System, Volume 8 : Astrocytoma, Medulloblastoma, Retinoblastoma, Chordoma, Craniopharyngioma, Oligodendroglioma, and Ependymoma 🔍
Tomohiro Osanai M.D., Chisato Katoh M.D., Ken Okumura M.D. (auth.), M.A. Hayat (eds.) Springer Science + Business Media BV, 10.1007/97, 2012
英语 [en] · PDF · 7.3MB · 2012 · 📘 非小说类图书 · 🚀/lgli/scihub/zlib · Save
描述
With tens of thousands of new CNS tumor cases each year in the US alone, this series of publications is a valuable aid to the diagnosis and treatment of these problematic neoplasms. Now, the eighth in the set returns to the topic of brain tumors, dealing with seven distinct types: astrocytoma, medulloblastoma, retinoblastoma, chordoma, craniopharyngioma, oligodendroglioma, and ependymoma. After updating the classification of medulloblastoma the volume provides an overview of ependymoma as well as describing the delineation of prognosis based on the genetic aberrations of the latter patients. The material offers key insights into the molecular pathways involved in tumor biology, such as the role of E-cadherin gene instability, carbonic anhydrase II, urokinase plasminogen activator, and Wnt signaling in meningioma. Contributors explain the genetic and clinical features associated with recurring meningioma, including the role played by erythropoietin receptor, and examine the way in which OTX2 transcription factor functions as an oncogene in medulloblastoma. With much more besides, including discussion of the molecular mechanisms that result in resistance to chemotherapy in medulloblastoma, this volume and its companions have a positive role to play in inspiring a new generation of researchers to design new drugs that are better targeted—and thus more effective.
备用文件名
zlib/no-category/Hayat, M.A/Tumors of the Central Nervous System, Volume 8 ||_54469488.pdf
备选作者
Scot P. Hillier
备选作者
Hayat, M.A.
备用出版商
Springer London, Limited
备用出版商
Springer Netherlands
备用版本
Tumors of the Central Nervous System, 8, Dordrecht, 2012
备用版本
Springer Nature, Dordrecht, 2012
备用版本
Netherlands, Netherlands
备用版本
Dordrecht, 2011-<2015>
元数据中的注释
sm22087397
备用描述
Advantages and limitations of biomarkers in gliomagenesis are described. Molecular subtypes of gliomas are detailed. The role played by TP53 gene mutation in the deadliest brain tumor, glioblastoma multiforme, is pointed out. The role of mutations of IDH1 and IDH2, and isocitrate dehydrogenases in malignant gliomas are presented. Metabolic differences in different regions of the glioma tumor are clarified. Various types of imaging modalities, including PET and SPECT, to diagnose gliomas in general and glioblastoma in particular in patients are explained in detail. Both low-grade and high-grade
开源日期
2015-07-14
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