Aspergillosis is an infection or allergic response caused by the fungus Aspergillus. Aspergillus conidia are widely dispersed in the environment and can easily reach human lungs and/or paranasal sinuses: most people inhale Aspergillosis spores every day!
The label Aspergillosis is used for several diverse clinical conditions. For instance, invasive Aspergillosis typically affects severely immunocompromised patients such as those with prolonged neutropenia or receiving therapy with steroids. On the other hand, allergic forms of Aspergillosis cause exuberant clinical syndromes that mostly affect patients with asthma and cystic fibrosis. Slowly destructive lung diseases may also occur in the apparently immunocompentent host, especially in the context of previous damage to the lung architecture. These are difficult-to-diagnose infections, and diagnostic tests perform differently depending on the specific scenario.
This book summarizes the current knowledge about Aspergillosis, covering:
* Epidemiology
* Pathogenesis
* Clinical manifestations
* Diagnosis
* Treatment
* Prevention
Written by internationally respected authors, the information presented in this book adds for a better understanding of Aspergillosis by providing a comprehensive and clear overview of all aspects associated with this complex disease.

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zlib/Medicine/David W. Denning (auth.), Alessandro Comarú Pasqualotto (eds.)/Aspergillosis: from diagnosis to prevention_5922783.pdf

Editor-alessandro Comarú Pasqualotto

Alessandro C. Pasqualotto, editor

Thorsten M. Buzug

Springer Science + Business Media BV

Dordrecht, New York, Netherlands, 2010

Springer Nature, Dordrecht, 2010

Netherlands, Netherlands

Dordrecht, cop. 2010

2010, 2009

sm23189095

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Includes bibliographical references and index.

Front Matter....Pages i-xvii
Front Matter....Pages 1-1
Introduction....Pages 3-5
Differences and Similarities Amongst Pathogenic Aspergillus Species....Pages 7-32
Immunology of Aspergillus and Aspergillosis: The Story So Far....Pages 33-52
The Importance of Conventional Methods: Microscopy and Culture....Pages 54-73
Molecular Methods for Identification of Aspergillus Species....Pages 75-85
The Pathology of Aspergillus Infection....Pages 87-104
Galactomannan Testing....Pages 105-124
β-D-Glucan Testing....Pages 125-133
Polymerase Chain Reaction (PCR)-Based Tests....Pages 135-157
Aspergillus Precipitins and Serology....Pages 159-169
Specific IgE Testing (RAST)....Pages 171-176
Molecular Typing of Aspergillus fumigatus Isolates....Pages 177-191
Antifungal Susceptibility Tests of Aspergillus Species....Pages 193-215
Antifungal Therapeutic Drug Monitoring for Invasive Aspergillosis....Pages 217-228
Azoles....Pages 230-262
Echinocandins....Pages 263-279
Polyene Antifungal Agents....Pages 281-305
5-Flucytosine....Pages 307-315
Terbinafine....Pages 317-325
Front Matter....Pages 327-327
Epidemiology of Invasive Pulmonary Aspergillosis....Pages 329-344
Front Matter....Pages 327-327
Pathogenesis of Invasive Pulmonary Aspergillosis....Pages 345-379
Clinical Manifestations of Invasive Pulmonary Aspergillosis....Pages 381-389
Diagnosing Aspergillosis: The Role of Invasive Diagnostic Interventions....Pages 391-405
Optimising the Use of Non-invasive Tests: From Blood to Radiology....Pages 407-422
Defining Invasive Aspergillosis: What the Revised EORTC/MSG Definitions Have in Store....Pages 423-435
Treatment of Invasive Pulmonary Aspergillosis....Pages 437-448
Antifungal Prophylaxis in Haematology....Pages 449-457
Invasive Aspergillosis in Paediatric Patients....Pages 460-483
Invasive Aspergillosis in the Intensive Care Unit: Beyond the Typical Haematological Patient....Pages 485-503
Aspergillosis in Surgical Patients....Pages 505-525
Invasive Aspergillosis in Chronic Granulomatous Disease....Pages 527-543
Aspergillosis in Drug Addicts....Pages 545-558
Invasive Aspergillosis and HIV Infection....Pages 559-566
Invasive Pulmonary Aspergillosis in Solid Organ Transplant Recipients....Pages 567-581
Front Matter....Pages 583-583
Chronic Cavitary Pulmonary Aspergillosis and Fungal Balls....Pages 585-620
Pathogenesis of Chronic Cavitary Pulmonary Aspergillosis: The Importance of the Host Immune System....Pages 621-642
Current Surgical Strategies for Chronic Cavitary Pulmonary Aspergillosis....Pages 643-651
Front Matter....Pages 655-655
Overview of Aspergillus Allergens....Pages 655-669
Epidemiology of Allergic Bronchopulmonary Aspergillosis....Pages 671-688
ABPA as an Occupational Disease....Pages 689-693
Front Matter....Pages 655-655
Pathogenesis of ABPA....Pages 695-706
Clinical Manifestations and Natural History of Allergic Bronchopulmonary Aspergillosis....Pages 707-724
How to Diagnose Allergic Bronchopulmonary Aspergillosis....Pages 725-745
The Treatment of ABPA....Pages 747-759
Severe Asthma with Fungal Sensitisation (SAFS)....Pages 761-775
Front Matter....Pages 777-777
Aspergillus Sinusitis....Pages 779-814
Front Matter....Pages 815-815
Aspergillus Overlap Syndromes....Pages 817-831
Front Matter....Pages 833-833
Cerebral Aspergillus Infections and Meningitis....Pages 835-852
Osteoarticular and Epidural Infections....Pages 853-862
Aspergillosis of the Digestive Tract....Pages 863-887
Cardiac Aspergillosis....Pages 889-903
Aspergillus Thyroiditis....Pages 905-911
Aspergillus Endophthalmitis....Pages 913-929
Urinary Tract Infections Caused by Aspergillus Species....Pages 931-937
Cutaneous and Wound Aspergillosis....Pages 939-959
Onychomycosis Due to Aspergillus Species....Pages 961-971
Aspergillus Keratitis....Pages 973-998
Aspergillus Otitis....Pages 999-1006
How to Diagnose Allergic Bronchopulmonary Aspergillosis....Pages E1-E23
Back Matter....Pages 1-21

Aspergillosis is an infection that mostly affects the respiratory system but can involve any other system in the body. This book examines the current state of the art in the prevention, diagnosis, therapy and management of all forms of aspergillosis.

Aspergillosis is an infection or allergic response caused by the fungus Aspergillus. This book covers epidemiology; pathogenesis; clinical manifestations; diagnosis; treatment; and, prevention

2020-08-30