The speed with which data must be collected and the complexity of its analysis have made computers an absolute necessity in the neurosciences. This book presents methods that range from the collection of neurophysiological data, through the control of laboratory equipment, the recording and identification of pulses, spikes and bursts, to cartographic methods and analysis of immunocytochemical and confocal microscopic data. The book describes the analysis of the kinetics of gene expression, receptor binding, behavioural data, graded potentials and fast axonal transport, and physical analysis. Modelling and simulations are presented for calcium oscillations and the IP3- sensitive calcium channel, ion gating, membrane potentials, individual neurons and neutral networks

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nexusstc/Computers and Computations in the Neurosciences: Methods in Neurosciences/31cb26cd7fb6e07990dfef8c954b9822.pdf

zlib/Biology and other natural sciences/P. Michael Conn (Eds.)/Computers and Computations in the Neurosciences: Methods in Neurosciences_2274818.pdf

Conn, P. Michael

Morgan Kaufmann Publishers

Brooks/Cole

Methods in neurosciences, v. 10, San Diego, ©1992

United States, United States of America

San Diego, London, England, 1992

Elsevier Ltd., San Diego, 1992

1 edition, 1992

November 1992

2, 1992

lg1105903

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Content:
Front Matter
Page iii
Copyright page
Page iv
Contributors to Volume 10
Pages ix-xiii
Preface
Pages xv-xvi
P. MICHAEL CONN
Methods in Neurosciences
Page xvii
Edited by, P. Michael Conn
[1] - Neurophysiological Data Acquisition Based on Personal Microcomputer System
Pages 3-12
Brian R. Stromquist
[2] - Personal Computer-Based Motion Control: A Tutorial and Application Using Simple Motor Controller to Drive Light Microscope Stage
Pages 13-31
Warren G. Tourtellotte
[3] - Single-Unit Isolation from Multiunit Nerves by Dedicated Recording and Computation Methods
Pages 32-47
Uwe T. Koch, Christian Hoock, Michael Brunner
[4] - Computers in Study of Simultaneously Recorded Spike Trains: Organization of Neuronal Assemblies
Pages 48-61
George L. Gerstein
[5] - Computer Methods in Nuclei Cartography
Pages 62-79
E.C. Hirsch, O. Lejeune, G. Colliot, G. Corkidi, M. Tajani
[6] - Quantitative Computerized Immunocytochemistry: Tissue Preparation and Image Analysis Techniques
Pages 80-93
Sverker Eneström
[7] - Confocal Fluorescence Microscopy in Three-Dimensional Analysis of Axon Terminal Distribution, Neuronal Connectivity, and Colocalization of Messenger Molecules in Nervous Tissue: Computerized Analysis
Pages 94-98,98a,98b,98c,98d,99-128
B. Ulfhake, K. Mossberg, K. Carlsson, U. Arvidsson
[8] - Computer-Assisted Quantitative Receptor Autoradiography
Pages 129-143
Louis Segu, Pierre Rage, Robert Pinard, Pascale Boulenguez
[9] - Measuring Spatial Water Maze Learning
Pages 144-152
Victor H. Denenberg, Gerry H. Kenner
[10] - Measuring Discrimination Learning
Pages 153-159
Victor H. Denenberg, Gerry H. Kenner
[11] - Computer Program for Kinetic Modeling of Gene Expression in Neurons
Pages 163-174
James L. Hargrove, Martin G. Hulsey, Diane K. Hartle
[12] - Computerized Optimization of Experimental Design for Estimating Binding Affinity and Binding Capacity in Ligand Binding Studies
Pages 175-195
Peter J. Munson, G. Enrico Rovati
[13] - Computerized Analysis of Opioid Receptor Heterogeneity by Ligand Binding in Guinea Pig Brain
Pages 196-216
Mario Tiberi
[14] - Identification of Spikes by Computer
Pages 217-227
F. Delcomyn, J.H. Cocatre-Zilgien
[15] - Computer Method for Identifying Bursts in Trains of Spikes
Pages 228-240
F. Delcomyn, J.H. Cocatre-Zilgien
[16] - Computer Algorithms for Deconvolution-Based Assessment of in Vivo Neuroendocrine Secretory Events
Pages 241-277
Johannes D. Veldhuis, William S. Evans, James P. Butler, Michael L. Johnson
[17] - Graded Action Potentials in Small Hippocampal Neurons: A Computational Approach
Pages 278-296
Staffan Johansson, Peter Århem
[18] - Quantification of Fast Axonal Transport by Video Microscopy
Pages 297-314
Hugo Geerts, Rony Nuydens, Roger Nuyens, Frans Cornelissen
[19] - Use of Computers for Quantitative, Three-Dimensional Analysis of Dendritic Trees
Pages 315-330
Brenda J. Claiborne
[20] - Interactive Computer-Assisted Coding, Three-Dimensional Reconstruction, and Quantitative Analysis of Neuronal Perikarya, Processes, Spines, and Varicosities
Pages 331-349
M. Freire
[21] - Computerized Three-Dimensional Analysis of Shape of Synaptic Active Zones in Rat Spinal Cord
Pages 350-362
W. Terrell Stamps, Claire E. Hulsebosch
[22] - Statistical and Computational Methods for Quantal Analysis of Synaptic Transmission
Pages 363-375
Dimitri M. Kullmann
[23] - Topography of Primary Muscle Afferent Neurons in Rat Dorsal Root Ganglia: A Three-Dimensional Computer-Aided Analysis
Pages 376-390
J.M. Peyronnard, J.P. Messier, L. Charron
[24] - Computerized Morphometric Analysis of Neurons in Culture
Pages 391-405
Erich Lieth
[25] - Computerized Analysis of Polarized Neurite Growth
Pages 406-418
R. John Cork
[26] - Computer-Assisted Methods for Analyzing Images of Olfactory Bulb
Pages 419-439
Jean P. Royet
[27] - Numerical Simulation of Cytosolic Calcium Oscillations Based on Inositol 1,4,5-Trisphosphate-Sensitive Calcium Channels
Pages 443-454
Stéphane Swillens
[28] - Models of Ion Channel Gating
Pages 455-472
Stephen W. Jones
[29] - Graphical Interactive Computer Simulation of Membrane Potential Measurements
Pages 473-491
Peter H. Barry
[30] - Computer-Assisted Three-Dimensional Reconstruction and Dissection
Pages 492-502
Robert Nagele, Kevin Bush, Dale Huff, Hsin-yi Lee
[31] - Computer Simulations of Individual Neurons
Pages 503-525
William R. Holmes
[32] - Factors Influencing Neuronal Density on Sections: Quantitative Data Obtained by Computer Simulation
Pages 526-548
C. Duyckaerts, P. Delaère, C. Costa, J.-J. Hauw
[33] - Physical Modeling of Neural Networks
Pages 549-567
Lipo Wang, John Ross
Index
Pages 569-584

Methods in Neurosciences, Volume 10: Computers and Computations in the Neurosciences discusses the use of computers in the neurosciences. The book deals with data collection, analysis, and modeling, with emphasis on the use of computers. Section I involves data collection using a personal microcomputer system. One paper presents a tutorial on using a PC-based motor control composed of an electronic circuit to adjust the motion of a light microscope stage through a software program. Other papers discuss computer methods in nuclei cartography and a computer-assisted quantitative receptor autoradiography in studying receptor density distribution. Section II deals with data analysis and some computer programs for kinetic modeling of gene expression in neurons. The book also discusses a computerized analysis of opioid receptor heterogeneity by ligand binding in test animals using computerized programs instead of employing manual or graphical methods. Computerized curve-fitting allows the researcher to utilize a more precise mathematical model to describe the binding of one ligand to one class of sites. Section III evaluates data modeling and simulations and describes the practicality of using computers to design model ion channels. Another paper discusses a graphical interaction program called MEMPOT to simulate an electrophysiological investigation of the properties of the membrane potential in stimulated cells. The book also presents a quantitative data gathered from computer simulation of the factors that affect neuronal density per measured sections. The book is suitable for microbiologists, biochemists, neuroscientists, and researchers in the field of medical research, as well as for advanced computer programmers in medical research work.

2013-12-20