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Metallopharmaceuticals I: DNA Interactions (Topics in Biological Inorganic Chemistry, 1) 🔍
Andrew Gelasco, Stephen J. Lippard (auth.), Professor Michael J. Clarke, Professor Peter J. Sadler (eds.) Springer-Verlag Berlin Heidelberg, Topics in Biological Inorganic Chemistry 1, 1, 1999
英语 [en] · PDF · 4.0MB · 1999 · 📘 非小说类图书 · 🚀/lgli/lgrs/nexusstc/scihub/zlib · Save
描述
Inorganic compounds offer much scope for the design of novel and therapeutic agents. The widespread use of paramagnetic metal complexes as effective contrast agents for magnetic resonsance imaging (e.g. Gd) demonstrates that the toxicity of metals can be finely controlled via the approriate choice of ligands. The successful targeting of radioisotopes again depends on ligand design and metal oxidation state. Bismuth and gold complexes have long been used in medicine but only recently have advances been made in understanding the molecular basis of their mechanism of action. New areas with clinical potential include the use of polyoxometallates and fullerenes as antiviral agents and vanadium complexes as insulin mimetics.
备用文件名
lgrsnf/A:\compressed\10.1007%2F978-3-662-03815-4.pdf
备用文件名
nexusstc/Metallopharmaceuticals I: DNA Interactions/556ff7370836616bdf42412323b71b65.pdf
备用文件名
scihub/10.1007/978-3-662-03815-4.pdf
备用文件名
zlib/Medicine/Andrew Gelasco, Stephen J. Lippard (auth.), Professor Michael J. Clarke, Professor Peter J. Sadler (eds.)/Metallopharmaceuticals I: DNA Interactions_2141951.pdf
备选作者
M. J Clarke; P. J Sadler; E Alessio
备用出版商
Spektrum Akademischer Verlag. in Springer-Verlag GmbH
备用出版商
Springer Spektrum. in Springer-Verlag GmbH
备用出版商
Steinkopff. in Springer-Verlag GmbH
备用出版商
Springer London, Limited
备用出版商
Springer Nature
备用版本
Topics in Biological Inorganic Chemistry Ser, Berlin, Heidelberg, 1999
备用版本
Topics in biological inorganic chemistry, 1, Berlin, Heidelberg, 1999
备用版本
Topics in biological inorganic chemistry, Berlin, 2011
备用版本
Softcover reprint of hardcover 1st ed. 1999, 2010
备用版本
Springer Nature, Berlin, Heidelberg, 2013
备用版本
Germany, Germany
备用版本
Dec 09, 2010
备用版本
1, 20130314
元数据中的注释
sm22930183
元数据中的注释
{"edition":"1","isbns":["3642084400","3662038153","9783642084409","9783662038154"],"last_page":200,"publisher":"Springer","series":"Topics in Biological Inorganic Chemistry 1"}
元数据中的注释
Source title: Metallopharmaceuticals I: Dna Interactions (Topics In Biological Inorganic Chemistry) (Topics in Biological Inorganic Chemistry (1))
备用描述
Front Matter....Pages I-XI
Anticancer Activity of Cisplatin and Related Complexes....Pages 1-43
Development of an Orally Active Platinum Anticancer Drug: JM216....Pages 45-71
trans -Platinum Compounds in Cancer Therapy: A Largely Unexplored Strategy for Identifying Novel Antitumor Platinum Drugs....Pages 73-98
Chemistry and Biology of Multifunctional DNA Binding Agents....Pages 99-115
Role of Metal Ions in Antisense and Antigene Strategies....Pages 117-142
Sulfoxide Ruthenium Complexes: Non-Toxic Tools for the Selective Treatment of Solid Tumour Metastases....Pages 143-169
Non-Platinum Antitumor Compounds....Pages 171-199
备用描述
Biological inorganic chemistry is a field of research at the interface of inorganic and biological chemistry. The rapidly developing insights into the role of metals in biological systems has far-reaching implications not only for biological science but also for related disciplines, ranging from molecular medicine to the environment. In each volume the reader, whether engaged in chemistry, biochemistry, biology or molecular medicine, receives a comprehensive summary and critical overview of a topic of high current interest written by leading international experts.
备用描述
<p>Each volume provides the reader, whether engaged in chemistry, biochemistry, biology or molecular medicine, with a comprehensive summary and critical overview of a topic of great current interest written by leading international experts.</p> <p>The book contains black-and-white illustrations.</p>
备用描述
With contributions by numerous experts
开源日期
2013-08-01
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