The discovery of uniform latex particles by polymer chemists of the Dow Chemical Company nearly 50 years ago opened up new exciting fields for scientists and physicians and established many new biomedical applications. Many in vitro diagnostic tests such as the latex agglutination tests, analytical cell and phagocytosis tests have since become rou­ tine. They were all developed on the basis of small particles bound to biological active molecules and fluorescent and radioactive markers. Further developments are ongoing, with the focus now shifted to applications of polymer particles in the controlled and di­ rected transport of drugs in living systems. Four important factors make microspheres interesting for in vivo applications: First, biocompatible polymer particles can be used to transport known amounts of drug and re­ lease them in a controlled fashion. Second, particles can be made of materials which bio­ degrade in living organisms without doing any harm. Third, particles with modified surfaces are able to avoid rapid capture by the reticuloendothelial system and therefore en­ hance their blood circulation time. Fourth, combining particles with specific molecules may allow organ-directed targeting.

lgrsnf/A:\Springer\bok%3A978-1-4757-6482-6.pdf

nexusstc/Scientific and Clinical Applications of Magnetic Carriers/564bf5bb2892d1acafd84ef28d27dc6a.pdf

scihub/10.1007/978-1-4757-6482-6.pdf

zlib/Medicine/Urs Häfeli (auth.), Urs Häfeli, Wolfgang Schütt, Joachim Teller, Maciej Zborowski (eds.)/Scientific and Clinical Applications of Magnetic Carriers_2250592.pdf

Springer Science & Business Media

Springer US : Imprint : Springer

United States, United States of America

Springer Nature, New York, NY, 2013

Boston, MA, 1997

New York, 1997

sm28143468

{"edition":"1","isbns":["1441932836","1475764820","9781441932839","9781475764826"],"last_page":628,"publisher":"Springer US"}

Front Matter....Pages i-xv
The Mystery and History of Magnetism....Pages 1-10
Preparation and Application of Monosized Magnetic Particles in Selective Cell Separation....Pages 11-35
Synthesis, Characterization, and Use of New Solid and Hollow, Magnetic and Non-Magnetic, Organic-Inorganic Monodispersed Hybrid Microspheres....Pages 37-51
Preparation and Characterization of Magnetic Nanospheres for in Vivo Application....Pages 53-67
Synthesis Studies on Paramagnetic Polystyrene Latex Particles....Pages 69-76
Microspheres for Use in a Novel Electromagnetic Bioadhesion Testing System....Pages 77-92
Novel Magnetic Microcarriers on the Basis of Poly(Vinyl Alcohol) for Biomedical Analysis....Pages 93-107
Magnetic Oxide Particles Prepared by Glass Crystallization....Pages 109-115
Nanosized Ferrite Particles....Pages 117-133
Intravenously Injected Particles....Pages 135-148
Analysis of Microspheres in Living Cells by Confocal Microscopy....Pages 149-161
Techniques for Electro- and Magnetokinetic Particle Characterization....Pages 163-170
Quantification of Maghemite Nanoparticles in Biological Media by Ferromagnetic Resonance and Its Alteration by Conjugation with Biological Substances....Pages 171-176
Use of ESR, Mössbauer Spectroscopy, and Squid-Magnetometry for the Characterization of Magnetic Nanoparticles on the Base of Metal Iron and Its Implications in Vivo....Pages 177-204
Physics of Magnetic Cell Sorting....Pages 205-231
Microfabricated Flow System for Magnetic Cell and Particle Separation....Pages 233-245
Continuous-Flow Magnetic Cell Sorting Using Soluble Immunomagnetic Label....Pages 247-260
Isolation of Megakaryocytes Using Magnetic Cell Separation....Pages 261-268
Magnetic Separation in Molecular Biology....Pages 269-285
Production of a Protein (Enzyme, Antibody, Protein A)-Magnetite Complex by Genetically Engineered Magnetic Bacteria Magnetospirillum Sp. AMB-1....Pages 287-294
Properties and Applications of Genetically Engineered Streptavidins....Pages 295-301
Application of Magnetic Particles in Immunoassays....Pages 303-309
Magnetomechanical Stimulation of Mesenchymal Cells....Pages 311-322
Overview of Magnetic Separations Used in Biochemical and Biotechnological Applications....Pages 323-340
Use of Immunomagnetic Carriers for the Rapid Detection of Virulent Bacteria from Biological Samples....Pages 341-351
Ferromagnetic and Immunomagnetic Concentration of Mycobacteria for the Diagnosis of Tuberculosis....Pages 353-357
In Vitro-Separation of Active Phagocytes for Temporary Extracorporeal Phagocytosis Assist by Magnetic Microbeads....Pages 359-369
Specific Blood Purification by Means of Antibody-Conjugated Magnetic Microspheres....Pages 371-378
Ferro-Carbon Particles....Pages 379-389
New Method of Biological Fluid Detoxification Based on Magnetic Adsorbents....Pages 391-397
Magnetic Maghemite Nanoparticles....Pages 399-417
Magnetic Measurements of Local Passage Velocity through the Gut....Pages 419-427
Magnetophoretic Characterization of the Plant Gravity Receptor....Pages 429-444
Targeting Magnetic Microspheres to Brain Tumors....Pages 445-455
Selected Preclinical and First Clinical Experiences with Magnetically Targeted 4’-Epidoxorubicin in Patients with Advanced Solid Tumors....Pages 457-480
MTC TM ....Pages 481-494
Magnetically Guided Drug Transport for the Prophylaxis of Pathological Conditions and the Protection of Implants....Pages 495-499
Magnetically Targeted Microspheres for Intracavitary and Intraspinal Y-90 Radiotherapy....Pages 501-516
A New Aids Therapy Approach Using Magnetoliposomes....Pages 517-526
Magnetic Nanoparticles as Contrast Agents for MR Imaging....Pages 527-543
Spio-Enhanced MR Lymphography....Pages 545-559
Superparamagnetic Iron Oxide Particles as Marker Substances for Searching Tumor Specific Liposomes with Magnetic Resonance Imaging....Pages 561-568
Magnetic Fluid Hyperthermia (MFH)....Pages 569-595
Use of Magnetic Nanoparticles for Thermolysis of Cells in a Ferrofluid....Pages 597-606
Physical Chemistry and in Vivo Tissue Heating Properties of Colloidal Magnetic Iron Oxides with Increased Power Absorption Rates....Pages 607-618
Back Matter....Pages 619-628

2013-12-12