1 online resource (xii, 209 pages) :
Neuropeptide Y (NPY) is a ubiquitous and important messenger in the nervous system, with a wide range of physiological roles. It is involved in the body energy balance and is one of the most potent stimuli of food intake known. NPY also acts to regulate central and peripheral autonomic functions. This book, written by academic and industrial experts in the field, links the most recent basic experimental knowledge about NPY and its receptors with areas of clinical importance. This book will be of interest to those working in all areas of research affected by NPY, such as food intake and energy homeostasis, cardiovascular regulation and G-protein-coupled receptors, as well as those interested in the development of drugs as NPY targets. Key Features * The hypothalamic role of NPY and its relationship with eating disorders and diabetes * The sympathetic nervous system role of NPY and its involvement in cardiovascular disorders * Characterization of NPY receptor types and their brain distribution, molecular biology and pharmacology * Development of peptide and non-peptide receptor antagonists
Multiple Receptors and Multiple Actions. Central Effects of Neuropeptide Y and Its Role in Obesity and Diabetes. Neuropeptide Y in Sympathetic Nerves-Evidence for Y1 Receptor-Mediated Vascular Control. Neuropeptide Y Receptor Types in Mammalian Brain. Species Differences and Status in the Human Central Nervous System. Extraordinary Structural Diversity of Neuropeptide Y Family Receptors. The Importance of Various Parts of the Neuropeptide Y Molecule for Receptor Recognition. Peptide Antagonists of Neuropeptide Y: Design, Structure, And Pharmacological Characterization. SR 120819A or the First Generation of Orally-Active Neuropeptide Y1 Receptor Antagonists. BIBP3226, A Potent and Selective Y1 Receptor Antagonist. First Structure-Activity Studies and Localization of the Human Y1 Receptor Binding Site. Discovery of Neuropeptide Y Receptor Antagonists. Subject Index
Includes bibliographical references and index
Print version record
Electronic reproduction. [S.l.] : HathiTrust Digital Library
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002
digitized 2010

Grundemar, Lars; Bloom, Stephen Robert

Elsevier Science & Technology Books

Morgan Kaufmann Publishers

San Diego: Academic Press

Woodhead Publishing Ltd

John Murray Press

Focal Press

Brooks/Cole

MyiLibrary

United Kingdom and Ireland, United Kingdom

United States, United States of America

1st edition, January 15, 1997

San Diego, c1997

Burlington, 1996

1, 1996

obscured text

<b>Neuropeptide Y (NPY)</b> is a ubiquitous and important messenger in the nervous system, with a wide range of physiological roles. It is involved in the body energy balance and is one of the most potent stimuli of food intake known. NPY also acts to regulate central and peripheral autonomic functions.<br>This book, written by academic and industrial experts in the field, links the most recent basic experimental knowledge about NPY and its receptors with areas of clinical importance.<br>This book will be of interest to those working in all areas of research affected by NPY, such as food intake and energy homeostasis, cardiovascular regulation and G-protein-coupled receptors, as well as those interested in the development of drugs as NPY targets.<br><br>Key Features<br>* The hypothalamic role of NPY and its relationship with eating disorders and diabetes<br>* The sympathetic nervous system role of NPY and its involvement in cardiovascular disorders<br>* Characterization of NPY receptor types and their brain distribution, molecular biology and pharmacology<br>* Development of peptide and non-peptide receptor antagonists

Y1 receptors are numerous in various regions of the brain and their distribution appears to be species specific.

2023-06-28