This volume is devoted to the chemistry, immunology, molecular biology, and physiology of the human chorionic gonadotropin, heG. For this glycoprotein molecule the course from discovery to chemical deciphering covered about fifty years. It was in 1928 that Ascheim and Zondek reported that urine from pregnant women contains something that stimulates the ovaries of mice or rats. This provided the basis for the famous A-Z test for pregnancy and for the "rabbit test" modification introduced by Friedman. As researchers sought to find more sensitive responses to heG, they used a wide variety of species including the South African aquatic toad, Xenopus Zaevis, the terrestrial toad of South America, Bufo arinarus, and the African weaver finch, EupZeetes afra. The weaver finch feather reaction was particularly noteworthy, for it disclosed a non-gonadal response to heG/LH. In retrospect, this may have been an important evolutionary clue to the realization that the designation of the hormone as a "gonadotropin" may have been only partially descriptive of the molecule's physiological function--a concept that is gaining attention, as the papers in this 1980 volume divulge.
Erscheinungsdatum: 22.02.2012

lgrsnf/A:\Springer\bok%3A978-1-4684-1062-4.pdf

nexusstc/Chorionic Gonadotropin/99e34d068fd422b15aaf9075d98b88b8.pdf

zlib/Medicine/Roy Hertz (auth.), Sheldon J. Segal (eds.)/Chorionic Gonadotropin_2249075.pdf

Sheldon J Segal; Rockefeller Foundation

Springer London, Limited

Plenum Press

United States, United States of America

Springer Nature, New York, NY, 2012

Boston, MA, 1981

Boston, MA, 1980

New York, ©1980

Feb 22, 2012

1980, 2012

1, 1980

lg1080111

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Front Matter....Pages i-ix
Early Studies of Chorionic Gonadotropin and Antihormones....Pages 1-15
Primary and Secondary Biologic Activities Intrinsic to the Human Chorionic Gonadotropin Molecule....Pages 17-35
Chorionic Gonadotropin in Rodents....Pages 37-51
Patterns of Secretion and Antigenic Similarities Among Primate Chorionic Gonadotropins: Significance in Fertility Research....Pages 53-63
Chemistry and Immunochemistry of Human Chorionic Gonadotropin....Pages 65-88
Chorionic Gonadotropins: Comparative Studies and Comments on Relationships to Other Glycoprotein Hormones....Pages 89-126
Structures of the Asparagine-Linked Sugar Chains of Human Chorionic Gonadotropin....Pages 127-145
Production and Secretion of hCG and hCG Subunits by Trophoblastic Tissue....Pages 147-175
Large Molecular Species of Human Chorionic Gonadotropin....Pages 177-197
Distribution, Metabolism, and Excretion of Human Chorionic Gonadotropin and Its Subunits in Man....Pages 199-212
Immuno-Biological Studies with Beta-Subunit of Human Chorionic Gonadotropin and Its Subfragments....Pages 213-230
Limitations and Problems of hCG-Specific Antisera....Pages 231-252
Human Chorionic Gonadotropin Alpha and Beta Subunit mRNAs: Translatable Levels During Pregnancy and Molecular Cloning of DNA Sequences Complementary to hCG....Pages 253-275
Human Chorionic Gonadotropin: Studies on the Mechanism of Secretion....Pages 277-294
Synthesis, Processing, and Secretion of Human Chorionic Gonadotropin Subunits by Cultured Human Cells....Pages 295-315
Regulation of Human Chorionic Gonadotropin Synthesis in Placenta, Choriocarcinoma, and Non-Placental Tumors....Pages 317-344
The Interaction of the LH/hCG Receptor with Adenylate Cyclase in the Rat Ovary....Pages 345-369
Testis-Determining H-Y Antigen and the Induction of the hCG Receptor....Pages 371-382
Presence of an hCG-Like Substance in Non-Pregnant Humans....Pages 383-409
Apparent Chorionic Gonadotropin Immunoreactivity in Human Non-Placental Tissues....Pages 411-419
Gonadotropin Produced by a Microorganism....Pages 421-434
Immunodetection of Choriogonadotropin-Like Antigen in Bacteria Isolated from Cancer Patients....Pages 435-460
A Bacterial Factor Cross-Reacting with Anti-CG....Pages 461-464
hCG Production by Non-Placental Tissue and Its Significance....Pages 465-489
Back Matter....Pages 491-507

2013-12-12