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nexusstc/Design and Optimization in Organic Synthesis/9bb3324e07b2ea30edb6b2439c3d25b2.djvu
Design and Optimization in Organic Synthesis, Third Edition (Data Handling in Science and Technology) 🔍
Rolf Carlson (Eds.) Elsevier Science & Technology Books, Data Handling in Science and Technology, Data Handling in Science and Technology 8, 3, 1992
英语 [en] · DJVU · 3.5MB · 1992 · 📘 非小说类图书 · 🚀/lgli/lgrs/nexusstc/zlib · Save
描述
This is the first general textbook on experimental design and optimization in organic synthesis. The book presents a unified methodology for carrying out systematic studies when the objective is to develop efficient and optimum synthetic methods. Strategies are included both for exploring the experimental conditions and for systematic studies of entire reaction systems (substrates, reagent(s) and solvents). The methodology is based on multivariate statistical techniques.
The following topics are treated in depth: classical two-level designs for screening experiments, gradient methods (steepest ascent, simplex methods) as well as response surface techniques for optimization, principal components analysis and PLS modelling.
The book is intended as a hands-on text for chemists and engineers engaged in developing synthetic methods in industrial research, e.g. in fine chemicals and pharmaceuticals production, as well as for advanced undergraduate students, graduate students, and researchers in an academic environment.
备用文件名
lgli/Carlson R. Design and Optimization in Organic Synthesis (Elsevier, 1991)(ISBN 044489201X)(T)(553s).djvu
备用文件名
lgrsnf/Carlson R. Design and Optimization in Organic Synthesis (Elsevier, 1991)(ISBN 044489201X)(T)(553s).djvu
备用文件名
zlib/Medicine/Rolf Carlson (Eds.)/Design and Optimization in Organic Synthesis_2077102.djvu
备选作者
Carlson, R.
备用出版商
Wolters Kluwer Legal & Regulatory U.S.
备用出版商
Woodhead Publishing Ltd
备用出版商
John Murray Press
备用出版商
Aspen Publishers
备用出版商
Focal Press
备用版本
Data handling in science and technology ;, v. 8, Amsterdam, New York, Netherlands, 1992
备用版本
Data handling in science and technology -- Vol. 8, Oxford, England, 1992
备用版本
Data handling in science and technology, 3rd ed, Amsterdam, 1992
备用版本
Data handling in science and technology, 3rd ed, Amsterdam, 2014
备用版本
United Kingdom and Ireland, United Kingdom
备用版本
United States, United States of America
备用版本
Elsevier Ltd., Amsterdam, 1992
备用版本
3, 1991
元数据中的注释
0
元数据中的注释
lg922991
元数据中的注释
{"container_title":"Data Handling in Science and Technology","edition":"3","isbns":["0080868355","044489201X","9780080868356","9780444892010"],"issns":["0922-3487"],"publisher":"Elsevier","series":"Data Handling in Science and Technology 8"}
元数据中的注释
Includes bibliographical references and index.
备用描述
Content:
Advisory Editors
Page ii
Edited by
Page iii
Copyright page
Page iv
Dedication
Page v
Foreword
Pages 1-4
Rolf Carlson
Chapter 1 Introduction: Strategies on different levels in organic synthesis
Pages 5-17
Chapter 2 Experimental study of reaction conditions. Initial remarks
Pages 19-30
Chapter 3 Models as tools
Pages 31-73
Chapter 4 General outline for screening experiments
Pages 75-88
Chapter 5 Two-level factorial designs
Pages 89-122
Chapter 6 Two-level fractional factorial design
Pages 123-177
Chapter 7 Other designs for screening experiments
Pages 179-199
Chapter 8 Summary of screening experiments
Pages 201-205
Chapter 9 Introduction to optimization
Pages 207-210
Chapter 10 Steepest ascent
Pages 211-224
Chapter 11 Simplex methods
Pages 225-248
Chapter 12 Response surface methods
Pages 249-324
Chapter 13 Summary of strategies to explore the experimental space
Pages 325-330
Chapter 14 The Reaction Space
Pages 331-336
Chapter 15 Principal properties
Pages 337-428
Chapter 16 Strategies for the selection of test systems
Pages 429-449
Chapter 17 Quantitative relations between observed responses and experimental variations
Pages 451-492
Chapter 18 A method for determining a suitable order of introducing reagents in “one-pot” procedures
Pages 493-498
Chapter 19 Concluding remarks
Pages 499-506
Appendices
Pages 507-529
Index
Pages 531-536
备用描述
This is the first general textbook on experimental design and optimization in organic synthesis. The book presents a unified methodology for carrying out systematic studies when the objective is to develop efficient and optimum synthetic methods. Strategies are included both for exploring the experimental conditions and for systematic studies of entire reaction systems (substrates, reagent(s) and solvents). The methodology is based on multivariate statistical techniques. The following topics are treated in depth: classical two-level designs for screening experiments, gradient methods (steepest ascent, simplex methods) as well as response surface techniques for optimization, principal components analysis and PLS modelling. The book is intended as a hands-on text for chemists and engineers engaged in developing synthetic methods in industrial research, e.g. in fine chemicals and pharmaceuticals production, as well as for advanced undergraduate students, graduate students, and researchers in an academic environment
开源日期
2013-05-27
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