Post Genomics Drug Discovery and Research explores and discusses some of the most important topics in post-genomics life and biopharmaceutical sciences. It provides an introduction to the field, outlining examples of many techniques currently used, as well as those still under development, which are important for the research of biopharmaceutical discovery in the post-genomics era.
Integrates several developing and cutting-edge technologies and methods like bioinformatics, experimental therapeutics, and molecular recognition Includes discussion on topics such as: computer-aided ligand design; peptide and protein chemistry and synthesis; synthesis of active natural products; and the use of emerging technologies like proteomics, nanotechnology, or bioengineering.

lgli/_364457.a170d92a5850d6ec91ea0453c99ff7d6.pdf

lgrsnf/_364457.a170d92a5850d6ec91ea0453c99ff7d6.pdf

zlib/no-category/Ziwei Huang (Author)/Drug Discovery Research: New Frontiers in the Post-Genomic Era_1080432.pdf

[edited by] Ziwei Huang

Huang, Ziwei

Jossey-Bass, Incorporated Publishers

Wiley & Sons, Incorporated, John

John Wiley & Sons, Incorporated

WILEY COMPUTING Publisher

Spectrum Publications

Halsted Press

United States, United States of America

Hoboken, NJ, United States, 2007

1., Auflage, New York, NY, 2007

Hoboken, N.J, New Jersey, 2007

1st ed, Hoboken, 2007

1, 2007-06-11

July 16, 2007

до 2011-08

lg641352

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Includes bibliographical references and index.

Molecular docking and structure-based design / P. Therese Lang ... [et al.]
Recent advances in drug discovery research using structure-based virtual screening techniques : examples of success for diverse protein targets / Sutapa Ghosh ... [et al.]
Virtual screening in drug discovery / Malcolm J. McGregor, Zhaowen Luo, Xuliang Jiang
Computer-aided drug design / Grace Shiahuy Chen and Ji-Wang Chern
Focused library design based on hit and target structures : method and application in drug discovery / Weiliang Zhu ... [et al.]
Beyond natural products : synthetic analogs of bryostatin 1 / Paul A. Wender ... [et al.]
The promises and pitfalls of small molecule inhibition of poly(ADP-ribose) glycohydrolase (PARG) / Amanda C. Nottbohm and Paul J. Hergenrother
Cyclic ADP-ribose analogues with minimal structure : synthesis and calcium-release activity / Lihe Zhang and Andreas H. Guse
Evaluation of neuroimmunophilin ligands / Junhai Xiao, Aihua Nie, Song Li
Chiral drugs and the associated asymmetric synthesis / Jiange Zhang and Guoqiang Lin
Alpha-helix mimetics in drug discovery / Hang Yin, Gui-In Lee, Andrew D. Hamilton
Basic and translational research of chemokine ligands and receptors and development of novel therapeutics / Won-Tak Choi ... [et al.]
Research progress in protein post-translational modification / Jia Hu, Yanting Guo, Yanmei Li
Controlled release of antibiotics encapsulated in nanoporous sol-gel materials with tunable pore parameters / Houping Yin, Laura Zheng, Yen Wei
Retinoic acid and arsenic trioxide treatment in acute promyelocytic leukemia-a model of oncoprotein targeted therapy / Jian-Hua Tong, Sai-Juan Chen, Zhu Chen.
2-chlorodeoxyadenosine (cladribine) : rational development of a novel chemotherapeutic agent / Howard B. Cottam and Dennis A. Carson
Apoptosis-based drug discovery for cancer / John C. Reed ... [et al.]
Mechanism-based development of memantine as a therapeutic agent in treating Alzheimer's disease and other neurologic disorders : low-affinity, uncompetitive antagonism with fast off-rate / Huei-Sheng Vincent Chen and Stuart A. Lipton
Bridging bench to clinic : roles of animal models for post-genomics drug discovery on metabolic diseases / Chi-Wai Wong and Ling Chen
Stem cell research and applications for human therapies / Prithi Rajan ... [et al.].

<p><P><b>Leading-edge research and technologies that facilitate drug discovery</b> <P>This definitive compilation of information on current drug discovery research reviews some of the most important topics in post-genomic biomedical and biopharmaceutical science, such as pharmacogenomics, structure-based drug design, medicinal chemistry, chemical biology, cancer biology, neuroscience, bio-nanotechnology, and stem cell research. <P>Including a Foreword by the late Nobel laureate Paul C. Lauterbur, and with contributions from seventy scholars and researchers from around the world, this book incorporates a general introduction to and practical examples of some of the many methods and techniques for the research of biopharmaceutical discovery in the post-genomic era. The contributors include experts in chemistry, structural biology, computation, biology, and medicine who have a common interest in translating research discoveries into new human therapies. In addition to exploring recent advances, they share their perspectives on various aspects of drug discovery research in the future. <P><i>Drug Discovery Research&#58; New Frontiers in the Post-Genomic Era</i> is a hands-on resource for practitioners and researchers in the pharmaceutical field and related industries, as well as a valuable reference for students in pharmaceutical science, chemistry, biology, biophysics, bioengineering, pharmacy, and medicine.</p>

xix, 521 p., [16] p. of plates : 25 cm

2011-08-31