Annotation With tens of thousands of new CNS tumor cases each year in the US alone, this series of publications is a valuable aid to the diagnosis and treatment of these problematic neoplasms. Now, the eighth in the set returns to the topic of brain tumors, dealing with seven distinct types: astrocytoma, medulloblastoma, retinoblastoma, chordoma, craniopharyngioma, oligodendroglioma, and ependymoma. After updating the classification of medulloblastoma the volume provides an overview of ependymoma as well as describing the delineation of prognosis based on the genetic aberrations of the latter patients. The material offers key insights into the molecular pathways involved in tumor biology, such as the role of E-cadherin gene instability, carbonic anhydrase II, urokinase plasminogen activator, and Wnt signaling in meningioma. Contributors explain the genetic and clinical features associated with recurring meningioma, including the role played by erythropoietin receptor, and examine the way in which OTX2 transcription factor functions as an oncogene in medulloblastoma. With much more besides, including discussion of the molecular mechanisms that result in resistance to chemotherapy in medulloblastoma, this volume and its companions have a positive role to play in inspiring a new generation of researchers to design new drugs that are better targetedand thus more effective

lgli/10.1007%2F978-94-007-4213-0.pdf

lgrsnf/10.1007%2F978-94-007-4213-0.pdf

scihub/10.1007/978-94-007-4213-0.pdf

zlib/Medicine/Oncology/M.A. Hayat, (ed.)/Tumors of the Central Nervous System, Volume 8: Astrocytoma, Medulloblastoma, Retinoblastoma, Chordoma, Craniopharyngioma, Oligodendroglioma, and Ependymoma_2203245.pdf

Hayat, M. A. (edt)

Scot P. Hillier

Springer Science + Business Media BV

Springer London, Limited

Tumors of the Central Nervous System Ser, New York, June 2012

Tumors of the Central Nervous System, 8, Dordrecht, 2012

Springer Nature, Dordrecht, 2012

Netherlands, Netherlands

Dordrecht, 2011-<2015>

2012, PS, 2012

sm22087397

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Front Matter....Pages i-xxxvii
Front Matter....Pages 1-1
Astrocytoma Cell Line: Role of Brain Natriuretic Peptide....Pages 3-11
Malignant Brain Astrocytomas: Extent of Resection Affects Survival....Pages 13-20
Front Matter....Pages 21-21
Medulloblastoma: Classification (A Review)....Pages 23-33
Medulloblastomas: Clinically Important MicroRNA Genes....Pages 35-46
Medulloblastoma: Role of OTX2 Transcription Factors....Pages 47-58
Molecular Mechanisms of Chemoresistance in Medulloblastoma....Pages 59-69
Extraneural Metastasis in Medulloblastoma....Pages 71-75
Medulloblastoma: Therapy with Bortezomib/Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand....Pages 77-83
Standard-Risk Medulloblastoma: Hyperfractionated Radiotherapy....Pages 85-90
Front Matter....Pages 91-91
Retinoma and Retinoblastoma: Genomic Hybridisation....Pages 93-102
Cell Cycle Control by Ataxia Telangiectasia Mutated Protein Through Regulating Retinoblastoma Protein Phosphorylation....Pages 103-115
Role of Survivin in Retinoblastoma: Diagnosis and Prognosis....Pages 117-124
Retinoblastoma Epigenetics....Pages 125-132
Retinoblastoma: Disease, Diagnosis, Therapy and Management....Pages 133-146
Long-Term Survivors of Retinoblastoma: Risk of Increased Second Malignancy....Pages 147-154
New Cancers Among Long-Term Survivors of Retinoblastoma....Pages 155-161
Front Matter....Pages 163-163
Chordoma: Role of CAM5.2....Pages 165-172
Chordomas and Chondrosarcomas: Treatment with Particle Radiotherapy....Pages 173-183
Skull Base Chordomas: Endonasal Endoscopic Transclival Approach....Pages 185-194
Front Matter....Pages 195-195
Craniopharyngioma: Comparison Between Supra-orbital Versus Endonasal Keyhole Approaches....Pages 197-210
Front Matter....Pages 195-195
The Expanded Endoscopic Endonasal Approach for Primary and Recurrent Craniopharyngiomas....Pages 211-221
Craniopharyngioma: The Role of Radiation....Pages 223-231
Cystic Craniopharyngiomas: Intratumoral Bleomycin Therapy....Pages 233-237
Front Matter....Pages 239-239
Anaplastic Oligodendroglioma Metastasized to Extraneural Sites....Pages 241-254
Recurrent Oligodendroglioma: Treatment with Bevacizumab....Pages 255-265
Front Matter....Pages 267-267
Ependymoma: An Overview....Pages 269-277
Ependymomas: Prognosis Based on Genetic Aberrations....Pages 279-286
Aberrant DNA Methylation in Ependymomas....Pages 287-295
Progressively Metastasizing Ependymoma: Genomic Aberrations....Pages 297-306
Extradural Ependymoma: Diagnosis Using Magnetic Resonance Imaging....Pages 307-312
Primary Malignant Ependymoma of the Abdominal Cavity: Diagnosis....Pages 313-320
Atypical Histologic Features and Patterns of Malignant Evolution in Tanycytic Ependymoma....Pages 321-329
Intracranial Ependymoma: Role for Chemotherapy....Pages 331-338
Back Matter....Pages 339-347

Advantages and limitations of biomarkers in gliomagenesis are described. Molecular subtypes of gliomas are detailed. The role played by TP53 gene mutation in the deadliest brain tumor, glioblastoma multiforme, is pointed out. The role of mutations of IDH1 and IDH2, and isocitrate dehydrogenases in malignant gliomas are presented. Metabolic differences in different regions of the glioma tumor are clarified. Various types of imaging modalities, including PET and SPECT, to diagnose gliomas in general and glioblastoma in particular in patients are explained in detail. Both low-grade and high-grade

2013-10-27