Linkage Studies In 16 St. Louis Families Present Status And Pursuit Of An Adjunct Strategy / Eric J. Devor. Editors Thomas N. Chase, Arnold J. Friedhoff, Donald J. Cohen. Drug Therapy Sections : P. 241-291. Includes Bibliographical References And Index.

Chase, Thomas N. (Thomas Newell), 1932-; Friedhoff, Arnold J., 1923-; Cohen, Donald J

New York: Raven Press

Raven Press, Limited

United States, United States of America

Volume 58, 1992

September 1992

xix, 377 pages :
Includes bibliographical references and index
Natural history of Tourette syndrome -- Diagnosis and classification of tics and Tourette syndrome -- Pathogenesis of Tourette syndrome: clues from the clinical phenotype and natural history -- Clinical phenomenology of tic disorders: selected aspects -- Tourette syndrome and obsessive-compulsive disorder: an analysis of associated phenomena -- Methodology of epidemiological studies of tic disorders and comorbid psychopathology -- Psychosocial factors in Tourette syndrome -- Population-based epidemiological study of Tourette syndrome among adolescents in Israel -- Epidemiology and comorbidity: the North Dakota prevalence studies of Tourette syndrome and other developmental disorders -- Tourette syndrome in a special education population: hypothesis -- Tourette syndrome and obsessive-compulsive disorder -- Comorbidity, Tourette syndrome, and anxiety disorders -- Self-injurious behavior and Tourette syndrome -- Immunohistochemical study of the basal ganglia in normal and parkinsonian monkeys -- Postmortem analysis of subcortical monoamines and amino acids in Tourette syndrome -- Neurochemical analysis of postmortem cortical and striatal brain tissue in patients with Tourette syndrome -- Basal ganglia peptidergic staining in Tourette syndrome -- Issues in genetic linkage studies of Tourette syndrome: phenotypic spectrum and genetic model parameters -- Tourette symptoms in 161 related family members -- Genetic study of Tourette syndrome in the Netherlands
Application of microsatellite DNA polymorphisms to linkage mapping of Tourette syndrome gene(s) -- Linkage studies in 16 St. Louis families: present status and pursuit of an adjunct strategy -- Alternative hypotheses on the inheritance of Tourette syndrome -- Structural imaging in Tourette syndrome -- SPECT imaging of cerebral blood flow in Tourette syndrome -- Functional neuroanatomy of Tourette syndrome: limbic-motor interactions studied with FDG PET -- PET studies on the integrity of the pre and postsynaptic dopaminergic system in Tourette syndrome -- Positron emission tomography evaluation of dopamine D-2 receptors in adults with Tourette syndrome -- Treatment of Tourette syndrome with neuroleptic drugs -- Clonidine and clonazepam in Tourette syndrome -- Neuroendocrine and behavioral effects of naloxone in Tourette syndrome -- Therapeutics of Tourette syndrome: new medicaiton approaches -- Methylphenidate in hyperactive boys with comorbid tic disorders: I. Clinic evaluations -- Psychopharmacology of obsessive-compulsive disorder in Tourette syndrome -- Effects of foods on the brain: possible implications for understanding and treating Tourette syndrome -- Is there a role for megavitamin therapy in the treatment of attention deficit hyperactivity disorder? -- Educational management of children with Tourette syndrome -- Family of Tourette syndrome -- Social adaptation of Tourette syndrome families in Japan -- Behavior therapy for obsessive-compulsive disorder and trichotillomania: implicaitons for Tourette syndrome -- Tourette syndrome: extending basic research to clinical care

"This volume presents an encyclopedic account of the past decade's achievements in the study and treatment of Tourette Syndrome (TS) and associated behavioral and psychiatric disorders. More than 90 of the foremost authorities from all relevant basic science, clinical, and behavioral science disciplines highlight the major recent developments worldwide - from groundbreaking genetic and neurochemical research and studies using state-of-the-art neuroimaging technologies, to new concepts on the clinical spectrum and natural history of TS, increasing recognition of comorbid conditions, and improved strategies for pharmacotherapy and psychosocial management." "The contributors assess the practical utility of current diagnostic criteria for TS and present extensive data on its natural history, its range of clinical manifestations, and its associated disorders. The findings indicate that the severity of TS varies widely among patients, that tics tend to diminish during adolescence and adulthood, and that comorbid conditions - such as obsessive-compulsive disorder and attention deficit hyperactivity disorder - are often the chief source of impairment. Much evidence suggests that these disturbances and the tics are manifestations of the same underlying diathesis." "Noted investigators document significant findings on the mode of inheritance for TS, define the key methodological issues in genetic linkage studies, and describe molecular approaches to the search for the genetic locus for the syndrome. The book also includes new data implicating specific monoamine neurotransmitters and endogenous opioid peptides in the pathogenesis of TS. Other contributors present neuroimaging studies using MRI, PET, and SPECT to delineate brain mechanisms involved in TS."

An encyclopaedic account of the achievements in the study of Tourette syndrome (TS) and associated disorders between 1980 and 1992. Coverage includes research on the genetics and neurochemistry of TS and neuroimaging studies using MRI, PET and SPECT to delineate underlying brain mechanisms.

2023-06-28