Bioinformatics - the use of computers to retrieve, process, analyze and simulate biological information - promises to revolutionize the process of drug discovery and development. This book provides a broad, application-oriented overview of this technology. Contributions by internationally renowned specialists in the field afford a detailed insight into single bioinformatics components and algorithmic methods. In addition, the state-of-the-art in bioinformatics is evaluated equally from a global view by introducing real application scenarios such as genome projects that require the use of a whole set of bioinformatics tools. The profound knowledge on bioinformatics presented here not only enables readers to go beyond a mere push-button approach to using bioinformatics software and interpreting the data generated appropriately. It is also essential to assess the potential and limitations of today's bioinformatics software and future challenges. Directed to all those involved in the use or development of new bioinformatics tools - scientists and managers from the fields of molecular biotechnology, pharmaceutics, and medicinal chemistry - this book will lead one step further on the way to rational drug design

lgrsnf/K:\_add\!woodhead\!woodhead1\Ebook - Misc\Bio Med\Chemogenomics in Drug Discovery - A Medicinal Chemistry Perspective - H. Kubinyi, G. Muller (Wiley, 2004) WW.pdf

nexusstc/Drug targeting : organ-specific strategies/e012645a6cd779f2613d08df06dfcfad.pdf

zlib/Medicine/Meijer, D. K. F.; Molema, Grietje/Drug targeting : organ-specific strategies_2697661.pdf

Molema G., Meijer D.K.F.

lg1488365

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How are medicines transported intact through the body to their specific target sites without triggering side effects? The answer is "Drug Targeting". This thoroughly application-oriented book gives comprehensive answers to this and many other questions that confront scientists daily in chemical, pharmaceutical and medical research. A concise overview of the most important basic theories, modern forms of therapy and molecular biological tools, it represents a comprehensible introduction to the topic. The book then goes on to deal with strategies for target applications, divided according to target site, for example brain, lungs, liver, blood vessels and tumor cells. The third part is devoted to special, modern techniques, from phage display methods, via the use of tissue slices right up to pharmacokinetic modeling. Throughout, the focus remains on the practical aspect and successful application of the method in question, although a glance at what the future holds is also included. A volume that every pharmaceutically oriented research group should own.

2016-04-05