This unique volume provides a mechanistic look at key aspects of the inflammatory response seen in critical illness. Key cells and mediators involved in the innate inflammatory response and the pathways employed to combat infection or respond to injury are emphasized. It has become clear that a delicate balance exists to allow eradication of infection with minimal immune-mediated tissue injury in the process. For this reason an up-to-date discussion of how the inflammatory response down regulates itself has been included. The inflammatory response in the critically ill is vastly different than in healthy hosts. For this reason, discussions about the mechanisms of pharmacologic immune suppression and other less commonly considered immunomodulated states seen frequently in critical care medicine have been included. Given the differences in immune function seen in critical illness, the importance of considering the immune system an organ whose function must be monitored and optimized for the best possible outcome has been highlighted. In addition, we have included up-to-date discussions of prevention and diagnostic approaches to extremely common infectious entities which must be monitored for and treated appropriately in the setting of critical illness induced immune dysfunction.

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Springer London, Limited

Molecular and cellular biology of critical care medicine, 3, Boston, MA, 2003

Molecular et Cellular Biology of Critical Care Medicine, 3, Boston, MA, 2003

Softcover reprint of the original 1st ed. 2003, 2012

United States, United States of America

Springer Nature, New York, NY, 2012

Oct 31, 2012

sm40065755

producers:
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Source title: Immunology and Infectious Disease (Molecular & Cellular Biology of Critical Care Medicine (3))

Front Matter....Pages i-ix
Host Microbicidal Actions of the Innate Immune Response....Pages 1-18
Activation of the Innate Immune Response in Critical Illness....Pages 19-39
Down-Regulation of the Immune Response....Pages 41-78
Mechanisms of Pharmacologic Immune Suppression....Pages 79-113
Modulation of the Immune Response in Critical Illness/Injury....Pages 115-153
Immune Monitoring and Strategies for Immune Modulation....Pages 155-185
Central Venous Catheter Related Infections: The Role of Antimicrobial Catheters....Pages 187-215
Discrimination of True Lower Respiratory Tract Infection in the Mechanically Ventilated Patient....Pages 217-239
Detection of Urinary Tract Infection in the Catheterized ICU Patient....Pages 241-255
Antimicrobial Choices and Dosing Strategies to Maximize Efficacy and Minimize the Development of Bacterial Resistance....Pages 257-270
Back Matter....Pages 271-276

Molecular & Cellular Biology of Critical Care Medicine
Erscheinungsdatum: 31.10.2012

2020-08-30