This book presents a collection of chapters on modern bioelectrochemistry, showing different aspects of biodevices. The chapters cover biomedical applications, virus and antigens detection, miniaturized and wearable devices, screen-printed biosensors, hybrids surfaces, point-of-care and molecular diagnoses. They provide relevant bibliographic information for researchers and students interested in field effect transistors for biomedical applications, virus and antigens detection in immuno technologies and biosensors in point-of-care for molecular analysis, with strategies and perspectives to healthcare. This book also presents insights on advantages and properties of materials aiming biosensors applications.
Erscheinungsdatum: 07.05.2022

lgli/310.pdf

lgrsnf/310.pdf

Springer Nature Switzerland AG

Switzerland, Switzerland

S.l.] :, 2022

Cham, 2022

producers:
Springer-i

Contents 5
Field-Effect Transistors for Biomedical Applications 6
1 Introduction 6
2 Biomedical Applications 7
2.1 Biosensors 7
2.2 Cell Interfaces 20
2.3 Tissue Interfaces 24
2.4 Others Biomedical Applications 26
3 Final Remarks and Challenges 28
References 30
Fundamentals for Virus and Antigen Detection in Immunotechnologies 36
1 Introduction 36
2 Biosensors and Immunoassays Designs 38
3 Proteins in Viral Detection 38
3.1 Proteins 38
3.2 Immune System and the Role of Antibodies 39
3.3 Antibodies Used in the Diagnosis of Viral Infection 40
3.4 Other Proteins as Antigens for Virus Immunodetection 42
3.5 Viral Proteins as Biomarkers 43
3.6 Viral Protein for Novel Coronavirus Detection (COVID-19) 44
4 Final Considerations 45
References 47
Miniaturized Electrochemical (Bio)sensing Devices Going Wearable 55
1 Introduction 55
1.1 Electrochemical Biosensors 56
1.2 The Role of Miniaturization 58
1.3 Wearable Electrochemical Devices 59
2 Components 61
2.1 Instrumentation 61
2.2 Electrodes 62
2.3 Substrates 66
2.4 Samples (Biological Fluids) 68
3 Operational Details 69
3.1 Electrochemical Methods/Transduction Under Wearable Settings 69
3.2 Data Transmission/Communication 71
3.3 Energy 73
3.4 Sampling 76
4 Applications of Wearable Electrochemical (Bio)sensors 78
4.1 Health Monitoring 78
4.2 Security and Environmental Monitoring 80
5 Considerations 82
References 84
Application of Large-Scale Fabrication Techniques for Development of Electrochemical Biosensors 95
1 Introduction 95
2 Enzymatic Biosensors 97
3 Immunosensors 103
4 Biosensors Using Nucleic Acids as Biorecognition Element 107
5 Conclusion and Outlook 110
References 111
Screen-Printed Electrochemical Sensors and Biosensors for Detection of Biomarkers 116
1 Introduction 116
1.1 Biomarkers 117
1.2 2D-Printed Electrochemical Devices 119
2 Electrochemical Determination of Biomarkers Using 2D-Printed Devices 126
3 Conclusions and Perspectives 137
References 137
Hybrids of Conducting Polymers and Carbon-Based Materials Aiming Biosensors Applications 144
1 Introduction 144
2 Biosensors Based on Hybrids of Conducting Polymers and Carbon-Based Materials 145
2.1 Environmental 145
2.2 Food 151
2.3 Diseases 155
2.4 DNA 160
3 Final Considerations 165
References 165
Biosensors in Point-of-Care: Molecular Analysis, Strategies and Perspectives to Health Care 171
1 Introduction 172
2 A Concise Historical Description 173
3 Applications 176
3.1 Personal or Bedside Care 176
3.2 Physician’s Office Testing 177
3.3 Hospital and Surgery-Room Level Monitoring 178
3.4 Field-Testing: From Food Safety Assessment to Military Hazards’ Scrutiny 179
3.5 Neglected Diseases Screening 180
3.6 Recent Miscellaneous of Tests: From COVID-19 Sensing to Forensics 180
4 Strategies, Materials and Surface Engineering 181
4.1 Electrode Materials 181
4.2 Sensing and Recognition: Enzymes, Mediators, DNAs, Aptamers and Antibodies 184
4.3 Manufacturing Strategies: Immobilisation, Screen-Printing, LAE, Embossing, Hydrogels, and Antibiofouling 187
4.4 Technological Advances: Miniaturisation, Integration, Automation, and Multiplexing 190
5 Conclusions and Future Perspectives 191
References 194

2024-01-20