The enteric plexuses
Interconnections between the plexuses
Extent of the ganglionated plexuses
Intramural extensions of extrinsic nerves
Electron microscope studies
Enteric glia
The structural similarities and functional differences between regions may have an evolutionary basis
Development of the enteric nervous system
Maturation of enteric neurons and development of function
Changes in enteric neurons with ageing
Summary and conclusions
Shapes of enteric neurons
Cell physiological classifications of enteric neurons
Functionally defined enteric neurons
Neurons in human intestine with equivalence to those investigated in laboratory animals
Summary and conclusions
Evolution of ideas about enteric circuitry
Motility controlling circuits of the small and large intestine
Intrinsic secretomotor and vasomotor circuits
Assemblies of neurons
Circuits in the esophagus and stomach
Co-ordination of motility, secretomotor and vasomotor reflexes
Circuits connecting the intestine, biliary system and pancreas
Sympathetic innervation of the gastrointestinal tract
Summary and conclusions
Chemical coding and multiple transmitters
Transmitters of motor neurons that innervate the smooth muscle of the gut
Transmitters at neuro-neuronal synapses
Sites within the reflex circuitry where specific pharmacologies of transmission can be deduced to occur
Transmission from entero-endocrine cells to ipans
Roles of interstitial cells of cajal in neuromuscular transmission
Transmitters of secretomotor and vasodilator neurons
Synapses in secretomotor and vasodilator pathways
Transmitters of motor neurons innervating gastrin cells
Summary and conclusions
Rhythmic activity of gastrointestinal muscle
Structure and properties of interstitial cells of cajal
Relationship between slow wave activity and neural control
Gastric motility
Patterns of small intestine motility and their intrinsic neural control
Motility of the colon
Neural control of the esophagus
Gall-bladder motility
Sphincters
Muscle of the mucosa
Mechanism of sympathetic inhibition of motility in non-sphincter regions
Sympathetic innervation of the sphincters
Physiological effects of noradrenergic neurons on motility in undisturbed animals
Reflex activities of sympathetic neurons that affect motility
Summary and conclusions
Water and electrolyte secretion in the small and large intestines
Reflex control of water and electrolyte secretion
Secretion of gastric acid
Pepsinogen secretion
Gastric secretion of bicarbonate
Secretion into the gall bladder
Pancreatic exocrine secretion
Summary and conclusions
Therapeutic end-points for motility disorders
Enteric neuropathies involving neuronal loss or phenotypic changes
Mitochondriopathies with intestinal manifestations
Irritable bowel syndrome and plasticity of enteric neurons.

Furness, John Barton

Wiley-Blackwell (an imprint of John Wiley & Sons Ltd)

United Kingdom and Ireland, United Kingdom

Malden, Mass, Massachusetts, 2006

OXFORD, Unknown

Oxford, 2005

Oxford, 2006

1, 2006

Includes bibliographical references and index.

This book brings together extensive knowledge of the structure and cell physiology of the enteric nervous system and provides a synthesis of the roles of the enteric nervous system in the control of motility, secretion and blood supply in the gastrointestinal tract. It includes sections on the enteric nervous system in disease, genetic abnormalities that affect enteric nervous system function, and targets for therapy in the enteric nervous system. It also includes many newly created explanatory diagrams and illustrations of the organization of enteric nerve circuits

John Furness covers all aspects of the structure, function, neurochemistry, transmitter identification and development of the enteric nervous system

2022-03-08