The ethics of care, developed in early 1980s within feminism as a critique on the biases of neokantian ethics, is 40 years old. This book presents its key insights, the developments and debates over the years and the challenges care ethics faces. Internationally renown scholars from various continents have contributed, a clear sign that care ethics has spread over the globe. The key insights regard issues close by, care from person to person, but also at an institutional level and questions of global impact. Vulnerability and relationality are examples of these insights. What can caring practices, ranging from social welfare to palliative care, learn from care ethics? Has care ethics had an impact on ethics at large and what is its future?"-- Información de la editorial

This collection of in-depth ethnographic analysis examines the impact of local and global transformations on the care, or lack of care, older people receive in Sub-Saharan Africa. This volume provides the pan-African evidence and analysis needed to move forward debates about how to address the long term care needs of this vulnerable population. Case studies from different regions of the continent (southern, central, east and west Africa) examine formal and informal care, including inter- and intra-generational care, retirement homes, care in the context of poverty, HIV/AIDS and migration.This collection of in-depth ethnographic analysis examines the impact of local and global transformations on the care, or lack of care, older people receive in Sub-Saharan Africa. This volume provides the pan-African evidence and analysis needed to move forward debates about how to address the long term care needs of this vulnerable population. Case studies from different regions of the continent (southern, central, east and west Africa) examine formal and informal care, including inter- and intra-generational care, retirement homes, care in the context of poverty, HIV/AIDS and migration

This book considers the question of spatial justice after apartheid from several disciplinary perspectives – jurisprudence, law, literature, architecture, photography and psychoanalysis are just some of the disciplines engaged here. However, the main theoretical device on which the authors comment is the legacy of what in Carl Schmitt’s terms is __nomos__ as the spatialised normativity of sociality. Each author considers within the practical and theoretical constraints of their topic, the question of what __nomos__ in its modern configuration may or may not contribute to a thinking of spatial justice after apartheid. On the whole, the collection forces a confrontation between law’s spatiality in a “postcolonial” era, on the one hand, and the traumatic legacy of what Paul Gilroy has called the “colonial __nomos__”, on the other hand. In the course of this confrontation, critical questions of continuation, extension, disruption and rewriting are raised and confronted in novel and innovative ways that both challenge Schmitt’s account of __nomos__ and affirm the centrality of the constitutive relation between law and space. The book promises to resituate the trajectory of __nomos__, while considering critical instances through which the spatial legacy of apartheid might at last be overcome. This interdisciplinary book will appeal to scholars of critical legal theory, political philosophy, aesthetics and architecture.

The world-renowned International Diagnostic Course in Davos (IDKD) represents a unique learning experience for imaging specialists in training as well as for experienced radiologists and clinicians. IDKD reinforces his role of educator offering to the scientific community tools of both basic knowledge and clinical practice. Aim of this Series, based on the faculty of the Davos Course and now launched as open access publication, is to provide a periodically renewed update on the current state of the art and the latest developments in the field of organ-based imaging (chest, neuro, MSK, and abdominal)

Inklusion ist zur zentralen pädagogischen Herausforderung geworden. Den hohen Erwartungen an einen inklusiven Umgang mit Behinderung, sprachlich-kultureller Diversität, Gender Diversity und sozialer Differenz stehen hartnäckige selektive Strukturen, eingefahrene Unterrichtspraktiken, politische Vorbehalte und teilweise auch Ängste entgegen. Die Grundfrage der generellen Umsetzbarkeit inklusiver Schule steht im Zentrum dieses Bandes. Die Beiträge über Erfahrungen im deutschsprachigen Raum und darüber hinaus in Skandinavien, Italien, Kanada, USA sowie afrikanischen und asiatischen Ländern berichten von Erfolgen, aber auch von Problemen in den länderspezifischen Erprobungen von Inklusion. Erscheinungsdatum: 01.08.2019

Die Bibliotheca Teubneriana, established in 1849, has evolved into the world's most venerable and extensive series of editions of Greek and Latin literature, ranging from classical to Neo-Latin texts. Some 4-5 new editions are published every year. A team of renowned scholars in the field of Classical Philology acts as advisory Gian Biagio Conte (Scuola Normale Superiore di Pisa)James Diggle (University of Cambridge)Donald J. Mastronarde (University of California, Berkeley)Franco Montanari (Universit� di Genova)Heinz-G�nther Nesselrath (Georg-August-Universit�t G�ttingen)Dirk Obbink (University of Oxford)Oliver Primavesi (Ludwig-Maximilians Universit�t M�nchen)Michael D. Reeve (University of Cambridge)Richard J. Tarrant (Harvard University) Formerly out-of-print editions are offered as print-on-demand reprints. Furthermore, all new books in the Bibliotheca Teubneriana series are published as eBooks. The older volumes of the series are being successively digitized and made available as eBooks.If you are interested in ordering an out-of-print edition, which hasn't been yet made available as print-on-demand reprint, please contact Kerstin.Haensch@degruyter.com All editions of Latin texts published in the Bibliotheca Teubneriana are collected in the online database BTL Online.

This proceedings volume compiles selected, revised papers presented at the 53rd SouthEastern International Conference on Combinatorics, Graph Theory, and Computing (SEICCGTC 2022), which took place at Florida Atlantic University in Boca Raton, USA, from March 7th to 11th, 2022. The SEICCGTC is widely regarded as a trendsetter for other conferences worldwide. Many ideas and themes initially discussed here have subsequently been explored in other conferences and symposia. Since 1970, the conference has been held annually in Baton Rouge, Louisiana, and Boca Raton, Florida. Over the years, it has grown to become the primary annual conference in its fields, playing a crucial role in disseminating results and fostering collaborative work. This volume is tailored for the community of pure and applied mathematicians in academia, industry, and government, who work in combinatorics and graph theory, as well as related areas of computer science and the intersections among these fields.

Quanti di voi hanno mai pensato che se certi eventi della vita vanno sempre storti potrebbe essere colpa della casa in cui abitate? Credo quasi nessuno.Ho una formazione scientifica e per natura sono sempre stata scettica su ciò che non tornava alla mia logica, ma dopo essere stata testimone di ciò che è successo a mia sorella, e le numerose ricerche che ho intrapreso, mi sono dovuta ricredere ...

Desde los diferentes aspectos del fenómeno migratorio, aborda su estudio de forma multidisciplinar, ahondando en su papel en la historia reciente de España y su reflejo en la lengua y la literatura.

Flirtations: Rhetoric and Aesthetics This Side of Seduction, opens by asking a fundamental first question: What is flirtation, and how does it differ from seduction? The essays thereby address the under-theorized terrain of flirtation not as a subgenre of seduction but rather as a phenomenon in its own right.

“A wide-ranging collection that allows the mask—as artifact, metaphor, theatrical costume, fetish, strategy for self-concealment, and treasured cultural object—to clarify modernity’s relationship to history.”—Carrie J. Preston, author of __Modernism’s Mythic Pose: Gender, Genre, Solo Performance__ “Covering an impressive range of geographies, cultures, and time periods, these carefully researched essays explore the fascinating role of masks and masking in mediating the relationship between tradition and modernity in both art and literature.”—Paul Jay, author of __The Humanities “Crisis” and the Future of Literary Studies__ Stretching beyond the Western canon and the literary scope of the field, this volume reconsiders what “modernism” means by exploring numerous local expressions of modernity around the globe. Masks—both literal and metaphorical—play a role in each of these artistic ventures, from Brazilian music to Chinese film to Nigerian masquerade performance. These case studies show how masks enable diverse artists and communities to grapple with deep societal transformations caused by modern transnational forces. The contributors challenge popular assumptions about what modernism looks like and what modernity is.

When EU member states signed the Treaty of Lisbon in 2007, they did not anticipate the manifold crises in store for them over the following years. Instead of the intended consolidation of a Union which had just gone through its most profound modernisation and biggest round of enlargements, the EU has since then had to weather a wide range of political, economic, social, legal, health and even military crises with major repercussions within and beyond its own territory. Indeed, this time of polycrisis has induced change on many levels: Across the continent and its many fora of European supra-, trans- and international collaboration, established institutions, rule systems and normative frameworks have been put into question and power balances have been shifting. Against this background, actors from social, political, economic and cultural life have sought new ways to overcome the manifold pressing problems of their time, be it through intensified collaboration or attempts to increasingly resolve issues at the national level. This volume offers a compilation of case studies on EU crisis responses, covering the most impactful of the various crises the EU has had to face in recent years. It provides theoretical and conceptual guidelines for the study of political actors’ responses to crisis at all levels of the EU multilevel governance system and beyond. * An overview of the most important events and developments shaping today’s EU policies and politics * Presentation of a framework for empirical research on the EU, its institutions and policies under crisis conditions and in the face of challenges

**__50 Years of Combinatorics, Graph Theory, and Computing__** advances research in discrete mathematics by providing current research surveys, each written by experts in their subjects. The book also celebrates outstanding mathematics from 50 years at the Southeastern International Conference on Combinatorics, Graph Theory & Computing (SEICCGTC). The conference is noted for the dissemination and stimulation of research, while fostering collaborations among mathematical scientists at all stages of their careers. The authors of the chapters highlight open questions. The sections of the book include: Combinatorics; Graph Theory; Combinatorial Matrix Theory; Designs, Geometry, Packing and Covering. Readers will discover the breadth and depth of the presentations at the SEICCGTC, as well as current research in combinatorics, graph theory and computer science. Features: * Commemorates 50 years of the Southeastern International Conference on Combinatorics, Graph Theory & Computing with research surveys * Surveys highlight open questions to inspire further research * Chapters are written by experts in their fields * Extensive bibliographies are provided at the end of each chapter

50 Years of Combinatorics, Graph Theory, and Computing advances research in discrete mathematics by providing current research surveys, each written by experts in their subjects. The book also celebrates outstanding mathematics from 50 years at the Southeastern International Conference on Combinatorics, Graph Theory & Computing (SEICCGTC). The conference is noted for the dissemination and stimulation of research, while fostering collaborations among mathematical scientists at all stages of their careers. The authors of the chapters highlight open questions. The sections of the book include: Combinatorics; Graph Theory; Combinatorial Matrix Theory; Designs, Geometry, Packing and Covering. Readers will discover the breadth and depth of the presentations at the SEICCGTC, as well as current research in combinatorics, graph theory and computer science. Features: Commemorates 50 years of the Southeastern International Conference on Combinatorics, Graph Theory & Computing with research surveys Surveys highlight open questions to inspire further research Chapters are written by experts in their fields Extensive bibliographies are provided at the end of each chapter

Existential Psychology East-Westis a collection of chapters exploring existential psychology in a cross-cultural context. The original version was published in preparation for the First International Conference on Existential Psychology held in Nanjing, China in 2010. This revised and expanded edition includes several updated chapters as well as four new chapters. The book consists of three sections. The first section provides an introduction to existential-humanistic psychotherapy along with a case illustration. Section two contains 13 chapters from Eastern and Western scholars exploring the theory of existential psychology. The third section contains 10 chapters building from Rollo May's work on myth. Each chapter explores the existential themes of a myth embedded within a particular cultural context. The book concludes with an Annotated Bibliography of important works in existential psychology. Existential Psychology East-Westis an important contribution to the field with many influential Eastern and Western scholars including Kirk Schneider, Xuefu Wang, Ilene Serlin, Mark Yang, Ed Mendelowitz, Heyong Shen, Erik Craig, Myrtle Heery, Alan G. Vaughan, Louis Hoffman, and Nathaniel Granger, Jr.

Providing a lively snapshot of the state of art and social justice today on a global level, Entry Points accompanies the inaugural Vera List Center Prize for Art and Politics, launched at The New School on the occasion of the center’s twentieth anniversary. This book captures some of the most significant worldwide examples of art and social justice and introduces an interested audience of artists, policy makers, scholars, and writers to new ways of thinking about how justice is defined, advanced, and practiced through the arts. In so doing, it assembles some of the latest scholarship in this field while refining our vocabulary for speaking about social justice, social engagement, community enhancement, empowerment, and even art itself.   The book's first half contains three essays by Thomas Keenan, João Ribas, and Sharon Sliwinski that map the field of art and social justice. These essays are accompanied by more than twenty profiles of recent artist projects that consist of brief essays and artist pages. This curated and carefully considered map of artists and projects identifies key moments in art and social justice.   The book's second half consists of an in-depth analysis of Theaster Gates's The Dorchester Projects, which won the inaugural Vera List Prize for Art and Politics. Produced to complement the project’s exhibition at the Sheila C. Johnson Design Center, Parsons School of Design in September 2013, this analysis illuminates Gates's rich, complex, and exemplary work. This section includes an interview between Gates and Vera List Center director Carin Kuoni; essays by Horace D. Ballard Jr., Romi N. Crawford, Shannon Jackson, and Mabel O. Wilson; and a number of responses to The Dorchester Projects by faculty in departments across The New School. Published by Duke University Press and the Vera List Center for Art and Politics at The New School

Volume 2 of this critical edition includes the translation of Volumes 3 and 4 of the second, revised French edition of Alexander von Humboldt’s __Essai politique sur le royaume de de Nouvelle Espagne__ from 1825 to 1827 as well as notes, supplements, indexes, and more. Alexander von Humboldt was the most celebrated modern chronicler of North and South America and the Caribbean, and this translation of his essay on New Spain—the first modern regional economic and political geography—covers his travels across today’s Mexico in 1803–1804. The work canvases natural-scientific and cultural-scientific objects alike, combining the results of fieldwork with archival research and expert testimony. To show how people, plants, animals, goods, and ideas moved across the globe, Humboldt wrote in a variety of styles, bending and reshaping familiar writerly conventions to keep readers attentive to new inputs. Above all, he wanted his readers to be open-minded when confronted with cultural and other differences in the Americas. Fueled by his comparative global perspective on politics, economics, and science, he used his writing to support Latin American independence and condemn slavery and other forms of colonial exploitation. It is these voluminous and innovative writings on the New World that made Humboldt the undisputed father of modern geography, early American studies, transatlantic cultural history, and environmental studies. This two-volume critical edition—the third installment in the Alexander von Humboldt in English series—is based on the full text, including all footnotes, tables, and maps, of the second, revised French edition of __Essai politique sur le royaume de de Nouvelle Espagne__ from 1825 to 1827, which has never been translated into English before. Extensive annotations and full-color atlases are available on the series website.

Análisis del discurso autoficcional contemporáneo en el drama, la lírica y el cine, partiendo de los inicios, la tradición y la recepción histórica de esta práctica literaria que juega con la autoría y la ficcionalidad.

HEMATOLOGY Basic Principles and Practice​ Copyright CONTENTS​ PART I MOLECULAR AND CELLULAR BASIS OF HEMATOLOGY.pdf 1 Anatomy and Physiology of the Gene The Genetic View of the Biosphere: The Central Dogma of Molecular Biology The Anatomy and Physiology of THE Gene DNA and RNA Structure Storage of Genetic Information in the Nucleotide Sequences of DNA Transmission of Genetic Information to the Next Generation The Expression of Genetic Information Via Translation Into Proteins Using the Genetic Code Regulation of Gene Expression Chromatin and the Epigenetic Regulation of Gene Expression Regulatory Sequence Motifs in or Near Genes: Enhancers, Promoters, and Silencers Transcription Factors Regulation at the Level of Pre-mRNA and mRNA Metabolism Pre-mRNA Splicing Modification of the Ends of the mRNA Molecule 5' and 3' Untranslated Sequences Within mRNAs That Modulate Stability and Translatability Transport of mRNA From Nucleus to Cytoplasm: mRNP Particles Regulation of mRNA Processing and Stability Regulation at the Level of mRNA Translation Heterogeneity of rRNAs and tRNAs Roles of Small Interfering RNAs, Micro RNAs, Short Hairpin RNAs, and Long Noncoding RNAs in Regulating Gene Expression Some Illustrative Structural Features of the Genome Relevant to Hematology Polymorphism and Single Nucleotide Polymorphisms Repeated Sequence Motifs Molecular Genetic Methodologies Allowing the Isolation, Analysis, and Manipulation of Genes The Polymerase Chain Reaction High-Throughput DNA and RNA Sequencing Gene Cloning Use of Transgenic and Knockout/Knockin Organisms to Model Gene Function DNA- and RNA-Based Therapeutics Gene Therapy and Gene Editing RNA Therapeutics Future Directions Suggested Readings 2 Epigenomics in Hematology Functional Chromatin Domains Dna Methylation Histones And Histone Variants Covalent Histone Modifications Transcription Factors Chromatin Remodelers Experimental Approaches in Epigenetics Mechanisms of Disease Epigenetic Therapies Future Directions Suggested Readings 3-s2.0-B978032373388500002X 3 Genomic Approaches to Hematology Introduction General Principles of Genomic Testing Genomic Analysis The Importance of Sample Quality Analytical Considerations Next-Generation Sequencing Technology RNA Profiling Noncoding RNA Mutation Detection Strategies Germline Versus Somatic Variants Point Mutations or Single Nucleotide Variants Structural Variation Copy Number Abnormalities Chromosomal Rearrangements Epigenomics The Clinical Utility of Genomics in Hematologic Malignancies Diagnosis Precision Medicine and Molecularly Targeted Therapies Risk-Stratified Therapy Response-Adapted Therapy and Minimal Residual Disease Monitoring Pharmacogenomics The Clinical Utility of Genomics in Benign Hematology The Hemoglobinopathies Clotting Disorders Disease with Rare Penetrant Variants Involving Multiple Loci Common Low Penetrance Risk Variants Approaches to the Development of Molecular Testing Suggested Readings References 4 Regulation of Gene Expression in Hematology Introduction Regulation of Transcription RNA Polymerase Binding and Regulation by Transcription Factors Regulation of Transcription by Chromatin Regulation of Transcription by DNA Modification RNA Proofreading Regulation of RNA Processing: Capping, Splicing, and Polyadenylation Nuclear Export of RNA RNA Heterogeneity Regulation of RNA Metabolism: Stability and Localization Regulation of RNA Stability by 5' and 3' UTR Sequences and Structures Nonsense-Mediated Decay RNA Modifications: The Epitranscriptome RNA Interference RNA Granules and Membraneless Organelles Protein Synthesis The Process of Translation Ribosome Disorders Protein Sorting Targeting of Nuclear Proteins Cotranslational Protein Translocation Into the Endoplasmic Reticulum Intra-Golgi Transport and Protein Processing Sorting Into Lysosomes Targeting of Mitochondrial Proteins Targeting of Peroxisomal Proteins Sorting into Regulated Secretory Granules Protein Folding and Posttranslational Modifications Protein Folding Protein Modifications Protein Folding and Modifications in the Endoplasmic Reticulum Protein Degradation Endoplasmic Reticulum-Associated Degradation and the Unfolded Protein Response Protein Degradation by the Proteasome Conclusions Suggested Readings References 5 Genome Editing Double-Stranded Dna Breaks: The Basis of Nuclease-Based Genome Editing Base Editing Other Genome Editing Systems Using Engineered Nucleases to Initiate the Genome Editing Process Genome Editing Using Only a Nuclease And Nonhomologous End-Joining Repair A Broad Range of Genomic Changes by Homologous Recombination–Mediated Genome Editing Genotoxicity Through Potential Off-Target Nuclease-Induced Double-Strand Breaks Genome Editing As a Research Tool Genome Editing As a Therapeutic Strategy Ex Vivo Manufacturing of Therapeutic Cells Therapeutic Genome Editing for Hematologic Diseases Sickle Cell Disease Fetal Hemoglobin Derepression Direct Gene Correction β-Thalassemia Fetal Hemoglobin Derepression Knocking HBB into HBA1 Primary Immunodeficiency Diseases Using the Blood System to Treat Nonhematologic Diseases (Metabolic Diseases) Genome Editing of Immune Effector Cells for Safer and More Potent Cancer Therapies (CAR-T Cells) Off-the-Shelf CAR-T Cells Increasing Potency Opportunities for Genome Editing in Vivo Challenges to in Vivo Editing of Hematopoietic Stem Cells Delivery Immunogenicity Heritable Genome Editing Suggested Readings References 6 Signaling Transduction and Metabolomics Signaling Transduction Receptor Tyrosine Kinases, Phosphoinosite-3-Kinase, and Mitogen-Activated Protein Kinase Pathways Receptor Tyrosine Kinases Phosphatidylinositol 3-Kinase Pathway MAPK/ERK Pathway The Transforming Growth Factor-β Pathway Signaling Through Receptors Associated With Protein-Tyrosine Kinases Cytokine Receptors and Janus-Activated Kinase Signaling Multichain Immune Recognition Receptors Integrin Signaling Tumor Necrosis Factor Receptors and Signaling Toll-Like Receptors and Signaling Wnt Signaling Notch Signaling Hedgehog Signaling Nuclear Hormone Receptor Superfamily G Protein–Coupled Receptor and Chemokine Signaling G Protein–Coupled Receptor Signaling Chemokine Signaling cGAS–cGAMP–STING Signaling Pathway Endoplasmic Reticulum Stress Signaling Pathways Heme Signaling Transduction Hypoxia Signaling Transduction Metabolomics and Control of Hematopoietic Cell Metabolism Glucose Metabolism Glycolysis Pentose Phosphate Pathway Tricarboxylic Acid or Krebs Cycle Oxidative Phosphorylation Reactive Oxygen Species Metabolism Lipid Metabolism Fatty Acid Synthesis Fatty Acid Oxidation Cholesterol Phospholipids Amino Acid Metabolism Biosynthesis of Nonessential Amino Acids Amino Acid Catabolism Nucleotide Metabolism Nucleotide Synthesis Nucleotide Degradation Introduction to Metabolomics Metabolomics of Glucose Metabolism Metabolomics of Lipid Metabolism Metabolomics of Nucleotide Metabolism Metabolomics of Amino Acid Metabolism Summary and Perspectives Suggested Readings 7 Protein Architecture: Relationship of Form and Function Amino Acids And The Peptide Bond Protein Secondary Structure Posttranslational Modifications The Domain Structure of Proteins The Immunoglobulin Domain and Variations The Protein Kinase Domain Membrane Proteins Future Directions Suggested Readings References 8 Pharmacogenomics and Hematologic Diseases Variation in the Human Genome Single-Nucleotide Polymorphisms Single-Nucleotide Polymorphisms and Phenotypes Structural Genomic Variants Somatic Genomic Variants Catalogs of Genomic Variants, Genotyping Platforms, and Genome-Wide Association Studies Variation in the Human Epigenome Genetic Variations Influencing Drug Response: Pharmacogenetics–Pharmacogenomics–Pharmacoepigenomics Optimization of Drug Therapy Genetic Variations That Influence Drug Disposition and Effects Drug Metabolism and Effects Pharmacogenomics of Thiopurines in Childhood Leukemia MP Dosage Adjustment According to the CPIC Guidelines Based on TPMT and NUDT15 Genotypes in Acute Lymphoblastic Leukemia Relapse of Acute Lymphoblastic Leukemia, Thiopurine Resistance, and Somatic Variants in NT5C2 and PRPS1 Glucocorticoid Pharmacogenomics in Childhood Acute Lymphoblastic Leukemia Inherited Genome Variants in Cytochrome P450 Enzymes Pharmacogenomics of Warfarin Drug Transporters SLCO1B1 and Methotrexate Genetic Variations Influencing Drug Targets BCR-ABL1 and Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia Adverse Drug Effects Presenting as Hematologic Disorders Glucose-6-Phosphate Dehydrogenase Deficiency and Rasburicase Drug Development Drug Development in Pediatric High-Risk B-Cell Acute Lymphoblastic Leukemia Identification of Novel Therapies for KMT2A-Rearranged Infant ALL Identification of Novel Therapies for “BCR-ABL1–Like” ALL Future Directions Suggested Reading References PART II CELLULAR BASIS OF HEMATOLOGY.pdf Chapter 9 Hematopoietic Stem Cell Biology Embryonic Origin of Hematopoietic Stem Cells Definition and Characterization of Hematopoietic Stem Cells Phenotype Murine Hematopoietic Stem Cells Human Hematopoietic Stem Cells CD49f+ Human Hematopoietic Stem Cells Functional Characterization In Vitro Assays In Vivo Assays Colony-Forming Unit–Spleen Assays Competitive Repopulation Assays Clonal Dynamics of Hematopoietic Stem Cells Regulation of Hematopoietic Stem Cell Fate Extrinsic Regulation NOTCH Signaling WNT Signaling Transforming Growth Factor-β and Hedgehog Signaling CXCL12–CXCR4 Signaling Intrinsic Pathways Transcription Factors Transcription Factors Required for the Specification of Hematopoietic Stem Cells Transcription Factors Required for Hematopoietic Stem Cell Homeostasis The Homeobox Cluster in Hematopoietic Stem Cell Self-Renewal Transcription Factor Networks Epigenetic Regulation of Hematopoietic Stem Cell Self-Renewal Regulation of Hematopoietic Stem Cells by Noncoding RNAs Hematopoietic Stem Cell Metabolism Novel Growth Factors For Expanding Hematopoietic Stem Cells and Clinical Testing Generating Hematopoietic Stem Cells From Pluripotent Stem Cells and by Reprogramming of Somatic Cells Hematopoietic Stem Cell Regeneration Hematopoietic Stem Cells and Malignancy (See Chapters 13 and 59) Suggested Readings References 10 Mitochondria and Hematopoiesis Mitochondrial Structure and Function Mitochondrial Diseases Mitochondrial Regulation of Hematopoietic Stem Cell Fates The Mitochondrial Unfolded Protein Response Mechanism The Mitochondrial Oxidative Self-Defense Response Mechanism Mitochondrial Dynamics Controls the Self-Renewing Potential of Hematopoietic Stem Cells Mitophagy as a Gatekeeper of Hematopoietic Stem Cells Fate Decisions Mitochondrial Metabolic Regulation of the Epigenetic Landscape of Hematopoietic Stem Cells Interaction Of Mitochondrial Network With The Bone Marrow Milieu Regulates Hematopoietic Stem Cell Fates Mitochondrial And Bone Marrow Roles In Leukemic Stem Cells And Aged Hematopoietic Stem Cells Mitochondrial and Epigenome Control Reprogramming Of Hematopoietic Stem Cells Concluding Remarks References 11 Cytokines, Chemokines, Other Growth Factors, and Their Receptors Introduction Cytokines And Their Modifying Influences Specifics Of Growth-Modulating Factors Colony-Stimulating Factors Interleukins Chemokines and Chemokine Receptors Role of Nuclear Factor-κB in Cytokine and Chemokine Gene Regulation, Inflammation, Immunity, and Cancer Engineered Cytokines and Role of Cytokines and Other Reagents for Preclinical and Clinical Ex Vivo Expansion of Hematopoiet ... Other Growth Modulating Proteins/Factors Iron-Binding Proteins Transforming Growth Factor-β, Associated-Inhibin Family Members, Bone Morphogenic Protein, Tumor Necrosis Factor-α, and Int ... Transforming Growth Factor-β Inhibins (Activin and Inhibin) Bone Morphogenetic Protein Tumor Necrosis Factor Interferons Additional Growth Modulating Factors Prostaglandin E Enzymes, Matrix Metalloproteinases, and Dipeptidylpeptidase 4, as Modifiers of Cytokine/Chemokine Biologic Activities Microenvironmental Niche and Role of Oxygen Tension in Hematopoiesis Exosomes/Extracellular Vesicles Aging in Context of Cell Regulation Radiation Effects on Hematopoiesis Concluding Thoughts Suggested Readings References 12 Role of Chemokines in Leukocyte Trafficking​ Chemokines Signaling by Chemokine Receptors Atypical Chemokine Receptors Chemokine Interaction With Glycosaminoglycans Leukocyte Entry Into Tissues Chemokine Control of Lymphocyte Homing to Secondary Lymphoid Organs Trafficking of Leukocytes From Blood Into Nonlymphoid Tissues Migration of Hematopoietic Stem Cells to the Bone Marrow and Mobilization in the Niche Leukocyte Migration Within Tissues Trafficking Patterns of Lymphocytes Migration of T Cells to T Zones Within Secondary Lymphoid Organs Positioning of B Cells Within Secondary Lymphoid Organs Leukocyte Exit From Tissues Reprogramming Dendritic Cells to Exit Tissues Toward Secondary Lymphoid Organs Egress of Lymphocytes From Secondary Lymphoid Organs Summary References Suggested Readings 13 Stem Cell Model of Hematologic Diseases Cell-Of-Origin Studies In Hematologic Malignancies Acute Myeloid Leukemia Myelodysplastic Syndromes Myeloproliferative Neoplasms Acute Lymphoblastic Leukemia Mature B-Cell Malignancies Chronic Lymphocytic Leukemia Hairy Cell Leukemia Diffuse Large B-Cell Lymphoma Follicular Lymphoma Conclusion References 14 Hematopoietic Microenvironment Evolution of The Niche Concept Hematopoietic Microenvironment During Development Adult Bone Marrow Microenvironment Hematopoietic Stem Cell Niches Location of the Hematopoietic Stem/Progenitor Cell Niche Cellular Components of the Hematopoietic Stem/Progenitor Cell Niche Osteolineage Cells Endothelial Cells Perivascular Cells Adipocytes Osteoclasts Bone Marrow Macrophages Megakaryocytes Extrinsic Regulation of the Hematopoietic Stem Cell Niche Sympathetic Innervation Hypoxia Niche Contribution to Leukemia Development Niche Alterations by Leukemia Therapeutic Targeting of Leukemic Niche Lymphoid Niches Erythroid Niches Megakaryocytic Niches Human Bone Marrow Microenvironment Hematopoietic Microenvironment in Acute Leukemia and Myelodysplasia Future Directions References 15 Cell Adhesion Adhesion Molecules Extracellular Matrix Proteins Integrins Immunoglobulin-Like Receptors Other Adhesion Receptors that Mediate Protein–Protein Interactions Lectin Adhesion Receptors Ligand Binding Versus Cell Adhesion Regulation of Adhesion Receptors Regulation of Synthesis Regulation of Surface Expression Regulation of Binding Affinity Cell Signaling Through Adhesion Molecules Cooperative Interactions Between Signaling and Adhesion Molecules Platelet Adhesion, Aggregation, and Hemostasis Leukocyte Rolling, Spreading, and Migration Across Vascular Endothelium During Inflammation Adhesion of T Cells to Antigen-Presenting Cells during Antigen Priming Genetic Deficiencies in Adhesion Molecules Dysregulated Expression of Adhesion Molecules Suggested Readings 16 Current Biology of Stem Cell Homing and Mobilization: Dynamic Interactions Between Hematopoietic Stem and Progenitor Ce ... Introduction Lessons from Steady-State Homeostatic Regulation of Hematopoietic Stem and Progenitor Cells Daily Light- and Darkness-Onset Induced Signals Maintain Blood Replenishment Together With Self-Renewal of Long-Term Repopu ... Mechanisms of Long-term Repopulating Stem Cell Chemotherapy Resistance via Anchorage to Their Supportive Bone Marrow Niches ... Hematopoietic Stem and Progenitor Cell Regulation via Dynamic Interactions With the Blood-BM Endothelial Barrier and the St ... Medical Approaches Originating from Understanding Mechanisms that Regulate Physiological Hspc Trafficking, for the Sake of ... Establishment of Functional Preclinical Immune-Deficient Mice Models to Study Human Hematopoietic Stem Cell Trafficking and ... Hematopoietic Stem and Progenitor Cell Homing The Essential Role of the CXCL12/CXCR4 AXIS in the Regulation of Hematopoietic Stem and Progenitor Cell Homing Hematopoietic Stem and Progenitor Cell Mobilization: A Dynamic Multi-Facet Process The CXCL12/CXCR4 Axis as a Driving Force Leading to Hematopoietic Stem and Progenitor Cell Mobilization Dynamics of the Hematopoietic Stem and Progenitor Cell Niches and the Bone Marrow Microenvironment During Mobilization Concluding Remarks Acknowledgments References 17 Control of Cell Division The Cell Division Cycle Quiescence and Differentiation G1 Phase S Phase G2 Phase M Phase Signaling T-Cell Receptor B-Cell Receptor Macrophage Colony-Stimulating Factor Receptor RAS Pathway to Cyclin D Cyclins and Cyclin-Dependent Kinases Cyclin-Dependent Kinase Inhibitors Transcriptional Regulation: MYC, RB-E2F, And Dream/Muvb Ubiquitination Deoxyribonucleic Acid Replication Mitosis Cell Cycle Checkpoints Competence Restriction Point G1/S Checkpoint S Phase Checkpoint G2/M Checkpoint Senescence Spindle Assembly Checkpoint Special Hematology Cell Cycle Features Hematopoietic Stem Cells Endoreplication References 18 Cell Death Core Apoptosis Pathways The Intrinsic Apoptotic Pathway Nonapoptotic Roles Of Bcl-2 Family Proteins The Death Receptor (Extrinsic) Pathway Of Apoptosis Nonapoptotic Forms Of Cell Death Necroptosis Ferroptosis Pyroptosis Cell Survival And Cell Death Pathways And Adaptive Responses To Stress Autophagy Unfolded Protein Response Clinical Applications Preclinical Activity Of Bcl2 Antisense And Bh3-Mimetics In Myeloid Malignancies Preclinical Activity of Oblimersen in Acute Myeloid Leukemia Preclinical Activity of Obatoclax in Acute Myeloid Leukemia Preclinical Activity of Navitoclax and ABT-737 in Acute Myeloid Leukemia Preclinical Activity of Single-Agent Venetoclax in Acute Myeloid Leukemia Combination Strategies to Boost Venetoclax Activity and Overcome Venetoclax Resistance Novel Venetoclax-Based Combinations Clinical Development Of Bh3-Mimetics For Myeloid Malignancies Clinical Development of Oblimersen for Acute Myeloid Leukemia Clinical Development of Obatoclax for Acute Myeloid Leukemia Clinical Development of Venetoclax for Acute Myeloid Leukemia Rationale For Use Of Bh-3 Mimetics In Chronic Lymphocytic Leukemia Clinical Development Of Venetoclax For Chronic Lymphocytic Leukemia Mechanisms Of Resistance To Venetoclax In Chronic Lymphocytic Leukemia Summary Suggested Readings References 19 Aging and Hematopoiesis Aging Hematopoietic Stem Cell Potential Declines With Aging Clinical Manifestations Anemia Immunosenescence Myelodysplastic Syndromes Leukemia Clonal Hematopoiesis, Clonal Hematopoiesis Of Indeterminate Potential, And Age-Related Clonal Hematopoiesis Mechanisms Of Hematopoietic Stem Cell Aging Intrinsic Factors DNA Damage Autophagy and Reactive Oxygen Species Epigenetic Modifications Chromatin Architecture and Polarity Extrinsic Factors Bone Marrow Microenvironment Senescence Inflammation Future Perspectives References PART III IMMUNOLOGIC BASIS OF HEMATOLOGY.pdf 20 Dendritic Cell Biology Dendritic Cell Subsets And Development Conventional Dendritic Cells Plasmacytoid Dendritic Cells Inflammatory Dendritic Cells Langerhans Cells New Developments in Dendritic Cell Classification Dendritic Cell Maturation Antigen Processing And Presentation MHC Class I Antigen Presentation (Endogenous Route) MHC Class II Antigen Presentation (Exogenous Route) Cross-Presentation Dendritic Cell-Mediated Immune Responses T Cells B Cells Innate Lymphoid Cells Other Elements of the Immune System Dendritic Cells In Disease Dendritic Cells and Autoimmunity Dendritic Cells and Immunodeficiency Dendritic Cells and Pathogens Dendritic Cells And Cancers Immunotherapeutic Strategies And Clinical Trials Future Directions Suggested Readings References 21 Natural Killer Cell Immunity AND THERAPY Natural Killer Cell Fundamental Biology Natural Killer Cell Subsets CD56dim Natural Killer Cells CD56bright Natural Killer Cells Natural Killer Cell Development Natural Killer Cell Receptors Killer-Cell Immunoglobulin-Like Receptors C-Type Lectin Receptors Natural Cytotoxicity Receptors Other Activating Receptors Adaptive Immune Properties Of Natural Killer Cells Natural Killer Cell Education Natural Killer Cell Memory The Role Of Natural Killer Cells In Human Disease Natural Killer Deficiency Syndromes Linked to Increased Infectious Risks The Role of Natural Killer Cells in Autoimmunity The Therapeutic Potential Of Natural Killer Cells Natural Killer Cells and Hematopoietic Cell Transplantation Infusion of Autologous Natural Killer Cells Infusion of Allogeneic Natural Killer Cells Expansion of Natural Killer Cells In Vivo via Cytokine Administration Killer-Cell Immunoglobulin-Like Receptors Blockade Natural Killer Cell Checkpoint Blockade Natural Killer Cell Antibody-Dependent Cytotoxicity Genetic Engineering of Natural Killer Cells Future Directions Suggested Readings References 22 B-Cell Development Stages of B-Cell Development Murine B-Cell Development Human B-Cell Development B Lineage Specification and Commitment Transcriptional Regulation of B-Cell Development MicroRNAs Immunoglobulin Gene Rearrangement Heavy Chain Gene Rearrangement Light Chain Gene Rearrangement The Immunoglobulin Recombinatorial Machinery Generation and Selection of the Primary B-Cell Repertoire The Pro-B- and Pre-B-Cell Checkpoints The Pro-B- to Pre-B-Cell Transition The Pre-B to B-Cell Transition The B-Cell Receptor The Hematopoietic Microenvironment Fetal B-Cell Development B-1 B Cells Secondary Lymphoid Tissues Anatomic Organization of Secondary Lymphoid Tissues Transitional B Cells Immune Responses in Secondary Lymphoid Tissues Germinal Centers Immunoglobulin Class Switching and Affinity Maturation Effects of Aging on B-Cell Development and Function References 23 Complement And Immunoglobulin Biology Leading To Clinical Translation​ The Complement System: An Overview Classical Pathway Lectin Pathway Alternative Pathway C3, C5, and the Membrane Attack Complex Complement Receptors and Their Role in Immune Complex Clearance and Activation Biologic Activity of C3a and C5a Regulation of Complement Activation Biologic Consequences of Complement Cascade Deficiencies Biologic Consequences of Complement Regulatory Protein Deficiencies and Function-Affecting Mutations Autoimmunity and Complement Deficiencies Natural Antibody Complement Links Innate and Adaptive Immune Responses Soluble Complement Mediators of Antibody Responses Complement Receptors and Antibody Responses B-Lymphocyte Coreceptors Focusing Antigen on Follicular Dendritic Cells Complement and T-Cell Immunity Complement and Cancer Complement and Coagulation Conclusion Immunoglobulins Properties and Structure Therapeutic Use Of Immunoglobulin Intravenous Immunoglobulin Adverse Events Related to Intravenous Immunoglobulin Infusion Early Systemic Events Infectious Disease Transfer High-Dose Treatment–Related Adverse Events Therapeutic Passive Immunization and Monoclonal Antibody Therapy Drugs Targeting The Complement System Eculizumab Ravulizumab New Anticomplement Drugs: Pegcetacoplan and Beyond References Suggested Readings 24 T-Cell Immunity T-Cell Activation Antigen Presentation: Creating the Ligand for the T-Cell Receptor The T-Cell Receptor Complex T-Cell Receptor Signal Transduction Co-Stimulation Spatial Coordination of T-Cell Receptor Signal Transduction: The Immunologic Synapse T-Cell Proliferation T-Cell Development Early T-Cell Development Positive Selection CD4 and CD8 Lineage Commitment Negative Selection T-Cell Function Th1 Cells Th2 Cells Th17 Cells Tfh Cells CD4+ Th Plasticity CD8+ Cytotoxic T Cells Maturation Of T-Cell-Mediated Immunity T-Cell Memory T-Cell Exhaustion: Impaired Response after Chronic Antigen Exposure Inhibition Of T Cell-Mediated Immunity Prevention of Inappropriate Initiation of T-Cell Responses Anergy Regulatory T Cells Limiting T-Cell Responses After Stimulation by Foreign Antigen Limitation of T-Cell Activity from Cell-Intrinsic Components Protein Tyrosine Phosphatases Cytotoxic T Lymphocyte Antigen-4 E3 Ubiquitin Ligases Diacylglycerol Kinases Limitation of T-Cell Activity From Cell-Extrinsic Components Terminating Immune Responses After Pathogen Clearance Therapeutic Manipulation Of T-Cell-Mediated Immunity Modulating T Cells to Permit Allograft Transplantation Manipulating T Cells to Improve Activity Against Malignancy Suggested Readings References 25 Unmodified Ex Vivo Expanded T Cells Adoptive Immunotherapy of Viral Infections with Virus-Specific T Cells Methods to Generate Virus-Specific T Cells Rapid Selection Ex Vivo Expansion Off-the-Shelf T-Cell Banks Adoptive Immunotherapy Of Cancer Adoptive Immunotherapy of Virus-Associated Malignancies Adoptive Immunotherapy of Virus-Independent Malignancies Neoantigens Mismatched Histocompatibility Antigens Non-Histocompatibility, Germline Antigens Future Directions Suggested Readings References 26 Treatment of Hematologic Malignancies With Genetically Modified T Cells Types of Cellular Immunotherapy Adoptive Cell Therapy With T Lymphocytes Allogeneic Donor Lymphocyte Infusion Infusion of Activated T Lymphocytes Genetic Modification of T Cells Artificial αβT-Cell Receptors Chimeric Antigen Receptors Clinical Results of Chimeric Antigen Receptor T Cells in Hematologic Malignancies CD19 B-Cell Maturation Antigen CD30 Acute Myeloid Leukemia Targets T-Cell Antigens Factors Affecting Response Toxicities of Chimeric Antigen Receptor T Cells Allogeneic Banked Cells Optimizing T-Cell Trafficking and Overcoming Tumor Immune Evasion T Lymphocytes, Transfer of Safety Genes, and Strategies to Improve Tumor Cell Specificity Future Applications and Implementation of Cell Therapies for Cancer ACKNOWLEDGMENT References PART IV DISORDERS OF HEMATOPOIETIC CELL DEVELOPMENT.pdf 27 Biology Of Erythropoiesis, Erythroid Differentiation, And Maturation Erythroid Cell Compartments Phenotypic and Functional Properties of Erythroid Progenitor Cells The Morphologically Recognizable Erythroid Precursor Cell Compartment Plasma Membrane and Cytoskeleton Reorganization Mitophagy and Ribosome and Mitochondria Clearance Nuclear Condensation and Enucleation Intrinsic Control of Erythropoiesis Extrinsic Control of the Erythropoiesis Erythropoietin Hematopoietic Microenvironment Erythropoiesis and Iron Regulation Cellular Dynamics in Erythropoiesis: Steady State and Stress Erythropoiesis Ontogeny of Erythropoiesis Erythroid Cells from in Vitro Generated Sources Suggested Readings References 28 Granulocytopoiesis and Monocytopoiesis Granulocytopoiesis Granulocyte Ontogeny Stages of Neutrophil Differentiation Markers of Granulocytic Maturation Neutrophil Granules and Their Content Proteins Control of Granulopoiesis Cytokine Regulation of Myeloid Proliferation and Differentiation Transcriptional Regulation of Myeloid Differentiation Transcription Factors Regulating Myeloid Differentiation and Myeloid-Specific Gene Expression Runx1 CCAAT Enhancer-Binding Protein Family of Transcription Factors. C/EBPα C/EBPβ C/EBPβ in Emergency Granulopoiesis Transcriptional Networks in Emergency Granulopoiesis C/EBPγ C/EBPδ C/EBPε C/EBPζ PU.1 Growth Factor Independence-1 CCAAT Displacement Protein Role of Developmentally Important Neutrophil-Specific Genes In Disease Severe Congenital Neutropenia and the Unfolded Protein Response Role of MicroRNAs in Controlling Gene Expression in Granulopoiesis Eosinophil Production Basophil and Mast Cell Production Monocytopoiesis Monocyte Ontogeny Stages of Monocyte Differentiation Markers of Monocyte Maturation Control of Monocytopoiesis Cytokine Regulation of Monocyte Proliferation and Differentiation Transcriptional Regulation of Monocyte Differentiation c-Jun Other Transcription Factors Modulating Monocyte Development Egr-1. C/EBPβ. MafB and c-Maf. Suggested Readings References 29 Thrombocytopoiesis Megakaryocyte Biology Megakaryocytopoiesis Cellular Hierarchy of Megakaryocyte Development Relationship Between Megakaryocytes and Hematopoietic Stem Cells Unique Features Of Megakaryocytes Endomitosis and Polyploidization The Endomitotic Cell Cycle Role of Endomitosis in Thrombocytopoiesis Mechanisms of Endomitosis in Megakaryocytes Cyclins and Cyclin-Dependent Kinases Other Mitotic Kinases Microtubules and the Mitotic Spindle The Spindle Checkpoint. Contractile Ring Activity Platelet Biogenesis Megakaryocytopoiesis in Ontogeny Tissue Distribution and Spatial Cues During Megakaryocytopoiesis Therapeutic Applications of Ex Vivo Megakaryocytopoiesis Cytokine Regulation Of Thrombocytopoiesis Thrombopoietin Signaling Thrombopoietin Thrombopoietin Receptor (c-Mpl) Thrombopoietin Receptor Downstream Signaling Pathways Negative Regulation of Thrombopoietin Signaling Regulation of Platelet Mass by Thrombopoietin Thrombopoietin Signaling in Disease Conditions Congenital Amegakaryocytic Thrombocytopenia (Chapter 30) Essential Thrombocythemia (Chapter 71) Additional Cytokines Involved in Megakaryocytopoiesis Therapeutic Cytokine Stimulation of Megakaryocytopoiesis Transcriptional Control Of Megakaryocytopoiesis GATA Family Transcription Factors GATA1 Friend of GATA (ZFPM1) X-Linked Dyserythropoietic Anemia and Thrombocytopenia Caused by GATA1 Mutations X-Linked Thrombocytopenia and Thalassemia Caused by GATA1 Mutations X-Linked Gray Platelet–Like Syndrome GATA1 Mutations in Down Syndrome Transient Myeloproliferative Disorders and Acute Megakaryoblastic Leukemia E26 Transformation Specific Family Transcription Factors Fli-1 ETS-Related Gene ETV6 (TEL) Other Transcription Factors RUNX1 NF-E2 p45 SCL (TAL1) Gfi-1b HOX-Related Genes MECOM (MDS1-EVI1) c-Myb Hypoxia-Inducible Factor 1-Alpha Micro Rnas In Megakaryocytopoiesis Future Directions Suggested References References 30 Inherited Bone Marrow Failure Syndromes Introduction Inherited Bone Marrow Failure Syndrome With Multi-Lineage Cytopenias Fanconi Anemia Background Epidemiology Genetics Pathophysiology Fanconi Anemia Genes and DNA Damage Repair Fanconi Anemia Genes, Cell Survival, and Balancing Oxidative Stress Pathogenesis of Bone Marro

This volume, one of the books in the "Making of Modern Freedom" series, is a collection of essays by eminent historians who explore the relationship between state finance and political development in fifteenth and sixteenth century Europe. They analyze how during this period European states were engaged in nearly continuous warfare and how those warfares produced fiscal crises. As a result, rulers were forced to enter into novel fiscal agreements with their subjects, often providing their subjects more political power, in exchange. The volume begins with two essays on England. David Harris Sacks traces the politics of government finance from the fifteenth century to the eve of the Civil War, and J. R. Jones carries the story forward into the eighteenth century, when representative government was jeopardized by new and powerful financial interests. The third essay, by Augustus J. Veenendaal, Jr., explains why the Netherlands' exceptional ability to raise money by taxes and loans allowed them to wage war without the severe financial difficultes experiencd by other European powers. Two essays on Spain by I. A. A. Thompson follow the changing fortunes of the Cortes of Castile, relating its role to the desperate manipulation of Spanish fiscal policy as it came into conflict with the dearly held liberties of Castilian citizens. The two final essays deal with the consequences of absolutism in France. Philip T. Hoffman details the fiscal effect of noble privileges and explores the political ramifications of the country's repeated financial crises, and Kathryn Norberg explains why the fiscal crisis of 1789 finally brought down the monarchy.

Taking the postcolonial – or, more specifically, the post-apartheid – university as its focus, the book takes the violence and the trauma of the global neoliberal hegemony as its central point of reference. Following a primarily psychoanalytic line of enquiry, it engages a range of disciplines – law, philosophy, literature, gender studies, cultural studies and political economy – in order better to understand the conditions of possibility of an emancipatory, or decolonised, higher education. And this in the context of both the inter-generational transmission of the trauma of colonialism, on the one hand, and, on the other, the trauma of neoliberal subjectivity in the postcolonial university. Oriented around an important lecture by Jacqueline Rose, the volume contains contributions from world-renowned authors, such as Judith Butler and Achille Mbembe, as well as numerous legal and other theorists who share their concern with interrogating the contemporary crisis in higher education. This truly interdisciplinary collection will appeal to a wide range of readers right across the humanities, but especially those with substantial interests in the contemporary state of the university, as well as those with theoretical interests in postcolonialism, psychoanalysis, gender studies, cultural studies, jurisprudence and law.

Narrative plays a central role for individual and collective lives - this insight has arguably only grown at a time of multiple social and cultural challenges in the 21st century. The present volume aims to actualize and further substantiate the case for literature and narrative, taking inspiration from Vera Nünning's eminent scholarship over the past decades. Engaging with her formative interdisciplinary work, the volume seeks to explore potentials of change through the transformative power of literature and narrative - to be harnessed by individuals and groups as agents of positive change in today's world. The book is located at the intersection of cognitive and cultural narratology and is concerned with the way literature affects individuals, how it works at an intersubjective level, enabling communication and community, and how it furthers social and cultural change. Erscheinungsdatum: 16.01.2023

This volume derives from a workshop on differential geometry, calculus of vari ations, and computer graphics at the Mathematical Sciences Research Institute in Berkeley, May 23-25, 1988. The meeting was structured around principal lectures given by F. Almgren, M. Callahan, J. Ericksen, G. Francis, R. Gulliver, P. Hanra han, J. Kajiya, K. Polthier, J. Sethian, I. Sterling, E. L. Thomas, and T. Vogel. The divergent backgrounds of these and the many other participants, as reflected in their lectures at the meeting and in their papers presented here, testify to the unifying element of the workshop's central theme. Any such meeting is ultimately dependent for its success on the interest and motivation of its participants. In this respect the present gathering was especially fortunate. The depth and range of the new developments presented in the lectures and also in informal discussion point to scientific and technological frontiers be ing crossed with impressive speed. The present volume is offered as a permanent record for those who were present, and also with a view toward making the material available to a wider audience than were able to attend. Erscheinungsdatum: 22.12.2011

When EU member states signed the Treaty of Lisbon in 2007, they did not anticipate the manifold crises in store for them over the following years. Instead of the intended consolidation of a Union which had just gone through its most profound modernisation and biggest round of enlargements, the EU has since then had to weather a wide range of political, economic, social, legal, health and even military crises with major repercussions within and beyond its own territory. Indeed, this time of polycrisis has induced change on many levels: Across the continent and its many fora of European supra-, trans- and international collaboration, established institutions, rule systems and normative frameworks have been put into question and power balances have been shifting. Against this background, actors from social, political, economic and cultural life have sought new ways to overcome the manifold pressing problems of their time, be it through intensified collaboration or attempts to increasingly resolve issues at the national level. This volume offers a compilation of case studies on EU crisis responses, covering the most impactful of the various crises the EU has had to face in recent years. It provides theoretical and conceptual guidelines for the study of political actors’ responses to crisis at all levels of the EU multilevel governance system and beyond. * An overview of the most important events and developments shaping today’s EU policies and politics * Presentation of a framework for empirical research on the EU, its institutions and policies under crisis conditions and in the face of challenges

This book provides a qualitative analysis of the process of consultancy, to prove how intercultural communication can solve issues rising from multiculturalism in organizations and policymaking. Experts in intercultural consultancy examine 12 different cases from real situations, focusing on interviews with clients and the way advice is presented and discussed with them, and on collected data and the process by which it is gathered. The book proves how the mechanisms of intercultural communication can be used to foster respectful relationships between people of different cultural and linguistic backgrounds and contribute to the success of the project or organization in question. This book will be a key resource for scholars and students involved in intercultural communication, management, and consultancy, as well as professionals that are confronted in their work with diversity and would like to know more about intercultural consultancy. Additional questions for discussion and readings are available as e-resources on the Routledge website. Cover 1 Half Title 2 Series 5 Title 6 Copyright 7 Contents 8 List of Figures and Images 11 List of Tables 12 List of Contributors 13 Foreword 18 1 Introduction 24 2 Key Concepts 28 Part I Policymakers 36 Case Study 1 Advising Municipalities on Schooling Newly Arrived Migrant Pupils 38 Case Study 2 Intercultural Communication Between a Municipality and Polish Migrants 45 Case Study 3 Internal Communication at the University of Aruba 57 Case Study 4 Lingua Receptiva at the Directorate-General for Translation (DGT) of the European Commission 68 Part II Commercial Organizations 78 Case Study 5 Acquisition Within One Country: How Two Organizational Cultures Come Together 80 Case Study 6 Enhancing Team Effectiveness for an Executive Team in Saudi Arabia 89 Part III Education 98 Case Study 7 Advising Parents on Bilingual Education of Their Children 100 Case Study 8 Advising Linguistically Diverse Schools on Developing a School-wide Language Policy 106 Case Study 9 Shifting From a Monolingual to a Plurilingual Pedagogical Practice 116 Part IV Non-Profit Organizations 126 Case Study 10 Improving Specialized Mental Healthcare and Social Services for Deaf and Hard of Hearing Newcomers 128 Case Study 11 A Model Village Constitution for Indigenous Traditional Leaders in Suriname 136 Case Study 12 Photographers’ Handling of Cultural Rituals and Conventions of Bereaved Parents After the Loss of a Child 147 Concluding Chapter 157 Subject Index 161 Name Index 165

Los trabajos aquí reunidos pretenden contribuir a la deconstrucción de la estructura binaria que de forma tradicional concibe un texto y su traducción en términos de original y copia.

Volume 1 of this critical edition includes a note on the text from the Humboldt in English team, an introduction by editors Vera M. Kutzinski and Ottmar Ette, a preface to the first edition by Alexander von Humboldt, and the translation of Volumes 1 and 2 of Humboldt’s __Essai politique sur le royaume de de Nouvelle Espagne__ from 1825 to 1827. Alexander von Humboldt was the most celebrated modern chronicler of North and South America and the Caribbean, and this translation of his essay on New Spain—the first modern regional economic and political geography—covers his travels across today’s Mexico in 1803–1804. The work canvases natural-scientific and cultural-scientific objects alike, combining the results of fieldwork with archival research and expert testimony. To show how people, plants, animals, goods, and ideas moved across the globe, Humboldt wrote in a variety of styles, bending and reshaping familiar writerly conventions to keep readers attentive to new inputs. Above all, he wanted his readers to be open-minded when confronted with cultural and other differences in the Americas. Fueled by his comparative global perspective on politics, economics, and science, he used his writing to support Latin American independence and condemn slavery and other forms of colonial exploitation. It is these voluminous and innovative writings on the New World that made Humboldt the undisputed father of modern geography, early American studies, transatlantic cultural history, and environmental studies. This two-volume critical edition—the third installment in the Alexander von Humboldt in English series—is based on the full text, including all footnotes, tables, and maps, of the second, revised French edition of __Essai politique sur le royaume de de Nouvelle Espagne__ from 1825 to 1827, which has never been translated into English before. Extensive annotations and full-color atlases are available on the series website.

The Memoirs of Sylvester Syropoulos is a text written by a Î’yzantine ecclesiastical official in the 15th century. Syropoulos participated in the Council for the union of the Greek and Latin Churches held in Ferrara and Florence, Italy, in 1438-1439. As a high-ranking official and an eye-witness of the union, he offers a unique perspective on this important political and religious event that would so decisively contribute to the political, military and religious development of Europe at the end of the Middle Ages. Experts in different fields - historians, philologists, art historians and archaeologists - have come together in this volume to explore the actions and motives of the various political and religious groups that participated in the council. With Syropoulos as their starting point, the contributors of this volume reconstruct the living conditions, cross-cultural interaction, artistic and commercial exchange in the 15th-century Mediterranean. At the same time, they discuss the text as an invaluable source for political and diplomatic affairs at that time, as a travel account, an eye-witness narrative and as a literary work. Emphasis is placed on Syropoulos’s Section IV where he describes the journey of the Byzantine delegation from Constantinople to Italy, their stay in Venice and in Ferrara, the diplomatic contacts with the doge and the pope, and finally the beginning of the council’s proceedings. An annotated English translation of the text is included as an appendix to the book. The papers bring out the richness of the information in Syropoulos’s writings about the people involved in the Council of Ferrara-Florence and especially the interaction among different social, religious and political groups throughout that event. His work is unique because it is a rare eye-witness account, deriving from personal experience, rather than an objective historical narrative.

Letters are famously easy to recognise, notoriously hard to define. Both real and fictitious letters can look identical to the point that there are no formal criteria which can distinguish one from the other. This has long been a point of anxiety in scholarship which has considered the value of an ancient letter to be determined by its authenticity, necessitating a strict binary opposition of genuine as opposed to fake letters. This volume challenges this dichotomy directly. Rather than defining epistolary fiction as a literary genre in opposition to ‘genuine’ letters or reducing it down to fixed rhetorical features, it argues that fiction is an inherent and fluid property of letters which ancient writers recognised and exploited. This volume contributes to wider scholarship on ancient fiction by demonstrating through the multiplicity of genres, contexts, and time periods discussed how complex and multifaceted ancient awareness of fictionality was. As such, this volume shows that letters are uniquely well-placed to unsettle disciplinary boundaries of fact and fiction, authentic and spurious, and that this allows for a deeper understanding of how ancient writers conceptualised and manipulated the fictional potential of letters.

This Anthology Provides Exciting, Innovative Research Focused On The Construction Of Adolescent Girls' Sexuality In The Media. The Volume Includes A Variety Of Theoretical And Methodological Perspectives From The Humanities And The Social Sciences, Addressing How Girls And Others Respond To, Work With, And Even Resist Prevailing Media Representations Of Girls' Sexualities And How They Use Contemporary Media As A Form Of Sexual Expression. The Authors Consider A Wide Array Of Sexual Attitudes, Behaviors, And Expressions Not Commonly Seen In The Sexualities Literature, Including The Voices Of Other Girls Whose Voices Are Often Ignored, Particularly Racial/ethnic Minority And Indigenous Girls, Sexual Minorities, And Girls From Non-u.s. Settings. The Use Of Ethnographic Data, In Conjunction With Media Analysis Techniques, Provides A Unique Approach To The Media Studies Genre, Which Tends To Highlight An Analysis Of Media Content, As Opposed To The Ways In Which Media Is Used In Everyday Life. -- Provided By Publisher. Girls' Sexualities And The Media : The Power Of The Media / Yasmina Katsulis, Vera Lopez, Kate Harper, And Georganne Scheiner Gillis -- The Girls Of Carvel : Adolescent Desire Ina Andy Hardy Films / Georganne Scheiner Gillis / Sensible Safety Rules : Class, Race, And Girls' Sexual Vulnerability In The U.s. Print Media, 1960-1970 / Jennifer Helgren -- Snogging, Stereotypes, And Subversion : Girls' Sexuality In The Harry Potter Series / Kate Harper -- The Pleasures Of Danger And The Dangers Of Pleasure : The Inversion Of Gender Relations In The Twilight Series / Suzan Walters And Michael Kimmel -- She's All That : Girl Sexuality And Teen Film / Catherine Driscoll -- Wrecked And Redeemed : Religio-political Pedagogy And Mtv's 16 And Pregnant / Amanda Rossie -- Just Say Me? (mis)representing Female Adolescent Sexual Agency On The Secret Life Of The American Teenager / Elena Frank -- Producing Girl Citizens As Agents Of Health : An Analysis Of Hpv Media Campaigns In The United States / Kellie Burns And Cristyn Davies -- Hyperfeminine Subcultures : Rethinking Gender Subjectivity And The Discourse Of Sexuality Among Adolescent Girls In Contemporary Japan / Isaac Gagné -- Favela Models : Sexual Virtue And Hopeful Narratives Of Beauty In Brazil / Alvaro Jarrin -- Chongas In The Media : The Ethno-sexual Politics Of Latina Girls' Hypervisibilty / Jillian Hernandez -- Hereroflexibility : Female Performance And Pleasure / Jennifer Apple -- Hey Media, Back Off And Get Off My Body : Spark Is Taking Sexy Back / Deborah L. Tolman, Lyn Mikel Brown, And Christin P. Bowman -- From Media Propaganda To De-stigmatizing Sex : Exploring A Teen Magazine By, For, And About Girls / Linda Charmaraman And Brittany Low -- We're All Straight Here : Using Girls' Groups And Critical Media Literacy To Explore Identity With Middle School Girls / Amy Rutstein-riley ... [et Al]. Edited By Kate Harper, Yasmina Katsulis, Vera Lopez, & Georganne Scheiner Gillis. Includes Bibliographical References And Index.

This book makes available in English important essays that mark the fortieth anniversary of the Second Vatican Council’s Declaration on the Relationship of the Church to Non-Christian Religions (Nostra Aetate). Surveying Vatican dialogues and documents, the essays explore challenging theological questions posed by the Shoah and the Catholic recognition of the Jewish people’s covenantal life with God. Featuring essays by Vatican officials, leading rabbis, diplomats, and Catholic and Jewish scholars, the book discusses the nature of Christian-Jewish relations and the need to remember their conflicted and often tragic history, aspects of a Christian theology of Judaism, the Catholic-Jewish dialogue since the Shoah, and the establishment of formal diplomatic relations between the Holy See and Israel. The book includes an essay by Cardinal Walter Kasper, president of the Pontifical Commission for Religious Relations with the Jews, and documents on the rapprochement between the Church and the Jewish people.

This volume explores Nordic textbooks chronologically and empirically from the Protestant reformation to our own time. The chapters are written by scholars from Finland, Denmark, Sweden, and Norway, and deploy a wide range of methods, representing different academic fields.

Die Kleinsten sicher behandeln Sie wünschen sich ein Nachschlagewerk, das Sie bei Ihrer Arbeit auf der Neugeborenenstation schnell und zuverlässig unterstützt. Dann greifen Sie zur Checkliste Neonatologie im kompakten Kitteltaschenformat. Alle relevanten Krankheitsbilder der Neonatologie konkret und praxisorientiert: - klare Handlungsanweisungen für die häufigsten Leitsymptome und typischen Notfälle - aktuelle Empfehlungen zu Diagnostik, Differenzialdiagnostik und Therapie - wichtige Informationen zu Reanimation und Hirntod - Dosierungen und Indikationen aller wichtigen Pharmaka - häufige ethische und juristische Fragen - Betreuung der Eltern in schwierigen Situationen Die Checkliste Neonatologie gibt Ihnen Sicherheit im Umgang mit den kleinen Patienten. Die Inhalte dieser Checkliste können Sie auch elektronisch nutzen. In der eRef. Online und – mit der eRef-App – auch offline. Damit haben Sie das perfekte „elektronische Kitteltaschenbuch“!

Alltagspraktische Handlungsoptionen trotz Dauerkrisenmodus entwickeln – und damit die Selbstwirksamkeit und die Produktivität steigernMenschen (nicht nur) in Unternehmen sind zunehmend mit Dystopien konfrontiert. Diese wirken sich auf die Stimmung und vor allem die Leistungsfähigkeit der Mitarbeitenden und Führungskräfte aus. Das Prinzip Hoffnung hilft zwar, trotz kritischer Lage positiver in die Zukunft zu blicken und ist als Erwartungshaltung hinsichtlich der eigenen Zukunft auch in der Forschung als „Schlüssel für ein besseres Leben“ gut belegt. Aber Hoffnung allein macht uns noch nicht handlungsfähig, wenn es darum geht, Zukunft aktiv zu gestalten.Zuversicht verstehen die Autorinnen als Kompetenz, mit klarem Blick auf die Realität und trotz der Herausforderungen Handlungsoptionen zu entwickeln, die dann im Ergebnis Veränderung zum Positiven ermöglichen. Der Unterschied zwischen „Ich hoffe, dass alles gut geht“ zu „Ich habe alles getan, dass es gut gehen wird“ beschreibt die für das Buch vorgenommene Unterscheidung der Begriffe.In der Forschung basiert Zuversicht auf den Unterkonstrukten „Hoffnung“, „Optimismus“, „Selbstwirksamkeit“ und „Resilienz“. Diese Begriffe werden, insbesondere in punkto Resilienz, im Buch zueinander in Beziehung gesetzt, um eine integrierte Perspektive zu ermöglichen.Das Buch unterstützt Führungskräfte, Unternehmer sowie Changemanagerinnen darin, alltagspraktische Handlungsoptionen trotz Dauerkrisenmodus zu entwickeln, hierüber Selbstwirksamkeitserleben und in der Folge Produktivität zu steigern und nicht zuletzt auch darin, Transformationsvorhaben positiv zu beeinflussen.Die im Buch dargestellten Cases stellen eine praktische, unmittelbar übertragbare Navigationsunterstützung für Führungskräfte, Unternehmen und Teams dar.Vera Starker, Wirtschaftspsychologin, MBA in systemischer Organisationsentwicklung, Autorin von diversen Sach- und Fachbüchern zum Thema Changemanagement und New Work, ist Mitgründerin und CEO des Berliner Think Tanks...

Relaciona las representaciones que en la historia oficial marcan la emergencia de un Estado libre, independiente y revolucionario en México, signado por las Guerras de Independencia de 1810 y la Revolución de 1910, con algunos procesos políticos y culturales de la época colonial.

This book offers a critical analysis of current challenges and developments of the State immunity regime through three dimensions: it looks at State immunity from a comparative perspective; it discusses the major trends relating to the interplay between State immunity and the protection of human rights as well as counter-terrorism; and it examines the relationship between State immunity and the financial obligations of States. Part I, Sovereign Immunity from a Comparative Perspective: Weak v. Strong Immunity Regimes, deals with the diversity of existing regimes of State immunity at the national level. This part aims to explore different approaches of particular states to sovereign immunity and their general attitude to international law, and attempts to understand why some States favour a weaker State immunity regime by multiplying exceptions or interpreting them broadly, while others continuously support a stronger one and sometimes rely on the doctrine of absolute immunity. Part II, International Customary Law of Sovereign Immunity, Human Rights and Counter-Terrorism, highlights how human rights and counter-terrorism have shaped the law and practice of sovereign immunity. This part specifically discusses the role of national legislators and judges in the development of international law, emerging conflicts between national constitutional norms and the rules of international law concerning State immunity and human rights, and possible ways of their reconciliation. Part III, Sovereign Immunity of States and their Financial Obligations, contributes to on-going debates related to the mixed and complex nature of States' financial obligations. In this part, authors elaborate on perceptions of the underlying public-private law divide, cross influences in public and private international law and their consequences for State immunity, as well as recent trends relating to immunity from execution.-- Provided by publisher

Fruit fly (Diptera: Tephritidae) pests have a profound impact on horticultural production and economy of many countries. It is fundamental to understand their biology and evaluate methods for their suppression, containment, or eradication . Area-Wide Management of Fruit Fly Pests comprises contributions from scientists from around the world on several species of tephritids working on diverse subjects with a focus on area-wide management of these pests. The first three sections of the book explore aspects of the biology, ecology, physiology, behavior, taxonomy, and morphology of fruit flies. The next two sections provide evidence on the efficacy of attractants, risk assessment, quarantine, and post-harvest control methods. The fifth and sixth sections examine biological control methods such as the Sterile Insect Technique and the use of natural enemies of fruit flies. The seventh section focuses on area-wide integrated pest management and action programs. Finally, the eighth section examines social, economic, and policy issues of action programs aimed at involving the wider community in the control of these pests and facilitate the development of control programs. Features: Presents information on the biology of tephritid flies. Provides knowledge on the use of natural enemies of fruit flies for their biological control. Includes research results on models and diets used for the Sterile Insect Technique. Reports developments on the chemical ecology of fruit flies that contribute to make control methods more specific and efficient. Reviews subjects such as Holistic Pest Management and Area-Wide Management Programs including social, economic, and policy issues in various countries. The Open Access version of this book, available at (https://www.taylorfrancis.com/books/9780429355738) https://www.taylorfrancis.com/books/9780429355738 , has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license.

Die Konstruktion von Tourismusräumen ist von verschiedenen gesellschaftlichen und kulturellen Prozessen begleitet. Welche Räume der Wahrnehmung, Nutzung und Aneignung werden dabei hergestellt? Wie gestaltet sich die soziale und kulturelle Produktion von Tourismusräumen? Die Beiträge dieses Bandes nähern sich diesen Fragen anhand unterschiedlicher gegenstandsbezogener Analysen. Zugleich wird aus kulturgeographischer und kulturwissenschaftlicher Perspektive das Potenzial der unterschiedlichen »Cultural Turns« für die empirische Analyse tourismusbezogener Fragestellungen ausgelotet. Erscheinungsdatum: 01.09.2010

Letters are famously easy to recognise, notoriously hard to define. Both real and fictitious letters can look identical to the point that there are no formal criteria which can distinguish one from the other. This has long been a point of anxiety in scholarship which has considered the value of an ancient letter to be determined by its authenticity, necessitating a strict binary opposition of genuine as opposed to fake letters. This volume challenges this dichotomy directly. Rather than defining epistolary fiction as a literary genre in opposition to ‘genuine’ letters or reducing it down to fixed rhetorical features, it argues that fiction is an inherent and fluid property of letters which ancient writers recognised and exploited. This volume contributes to wider scholarship on ancient fiction by demonstrating through the multiplicity of genres, contexts, and time periods discussed how complex and multifaceted ancient awareness of fictionality was. As such, this volume shows that letters are uniquely well-placed to unsettle disciplinary boundaries of fact and fiction, authentic and spurious, and that this allows for a deeper understanding of how ancient writers conceptualised and manipulated the fictional potential of letters.

From 1955 to 1975, Vera Pigee (1924–2007) put her life and livelihood on the line with grassroots efforts for social change in Mississippi, principally through her years of leadership in Coahoma County’s NAACP. Known as the “Lady of Hats,” coined by NAACP executive secretary Roy Wilkins, Pigee was a businesswoman, mother, and leader. Her book, The Struggle of Struggles , offers a detailed view of the daily grind of organizing for years to open the state’s closed society. Fearless, forthright, and fashionable, Pigee also suffered for her efforts at the hands of white supremacists and those unwilling to accept strong women in leadership. She wrote herself into the histories, confronted misinformation, and self-published one of the first autobiographies from the era. Women like her worked, often without accolade or recognition, in their communities all over the country, but did not document their efforts in this way. The Struggle of Struggles , originally published in 1975, spotlights the gendered and generational tensions within the civil rights movement. It outlines the complexity, frustrations, and snubs, as well as the joy and triumphs that Pigee experienced and witnessed in the quest for a fairer and more equitable nation. This new edition begins with a detailed introductory essay by historian Françoise N. Hamlin, who interviewed Pigee and her daughter in the few years preceding their passing, as well as their coworkers and current activists. In addition to the insightful Introduction, Hamlin has also provided annotations to the original text for clarity and explanation, along with a timeline to guide a new generation of readers.

This book gives a multidisciplinary perspective on complications of female pelvic surgery. The confined space of the pelvis precludes a clear separation of the pelvic surgical disciplines, and pelvic surgery is therefore multidisciplinary by nature. This work addresses this overlap by featuring three editors, one from each of the major pelvic surgery disciplines: gynecology, urology, and colorectal surgery. The chapters are broken down into medical, surgical, and procedure-related complications, and address each complication’s background, prevention, recognition, and management. Written by experts in the field, this book is an easy-to-use resource for all surgeons who perform pelvic operations.

Der Band widmet sich den Wechselbeziehungen, Wechselwirkungen, aber auch Analogien und auffälligen Divergenzen zwischen Kunst, Literatur und Wissenschaft im Wien der Jahrhundertwende sowie in der ukrainischen Moderne und Avantgarde. Die kulturellen Beziehungen zwischen der Ukraine und Österreich werden gerade nach 1918 immer spärlicher, dennoch scheint es lehrreich, die Affinitäten und Kontraste zwischen den zunehmend auseinanderdriftenden kulturellen Räumen zu beschreiben und zu beobachten. Der Band macht zudem viele beeindruckende ukrainische Forschungsleistungen erstmals in deutscher Sprache zugänglich. Überdies enthält er umfangreiches Bildmaterial zur ukrainischen literarischen und bildkünstlerischen Avantgarde sowie zum futuristischen und konstruktivistischen Bühnenbild. Erscheinungsdatum: 20.04.2016

Introduzione, traduzione e note di Quintino Cataudella Prima edizione BUR 1990 Sedicesima edizione BUR Classici greci e latini febbraio 2017 Testo greco a fronte Il testo greco riproduce l'edizione a cura di M.D. Macleod, "Luciani Opera", vol. I, Bibliotheca Oxoniensis, Oxford Classical Texts, 1972. © Δημοδάμας ὁ Ἁλικαρνασσεύς (ἢ Μιλήσιος) 2018

Kaum ein anderes Thema verbindet Ästhetik und Moral so sehr wie ›Natur‹. Der Aspekt der moralischen Überlegenheit wurde der Natürlichkeit im Laufe der Geschichte immer wieder zugeschrieben und umgekehrt das moralische Gesetz aus der Natur legitimiert. Ausgangspunkt dieses Bandes ist das mittlere 18. Jahrhundert, in welchem die Bühnenästhetik von der Forderung nach Natürlichkeit als Gegenposition zu den barocken Affekten gekennzeichnet war. Beiträge aus der Kunstgeschichte, Tanztheorie, Theater-, Kultur- und Musikwissenschaft sowie der Praxis der Theater- und Opernregie diskutieren die Forderungen nach Natürlichkeit und Einfachheit. Vor etwa 250 Jahren prägten diese die Debatten um den ›natürlichen Menschen‹ oder ›edlen Wilden‹ in gesellschaftspolitischen, aber auch in bühnen- und musikästhetischen Diskursen. Es zeigt sich einmal mehr: Was Natur ist, bestimmt die Kunst. Erscheinungsdatum: 01.05.2019